Evidence map›Paper›PMID 28205052›Full record

ArticleVirus genes2017

A novel subgenotype 3a hepatitis E virus isolated from pigs in China.

Yufeng Cao, Lisai Zhu, Dan Liu, Changming Guo, Yue Yuan, Chengbo Shi, Zhaohui Liu, Xinping Wang

Abstract read
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In one paragraph

Article in Virus genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Development of new hepatitis E vaccines.Human vaccines & immunotherapeutics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yufeng CaoCollege of Veterinary Medicine, Jilin University, 5333 Xian Road, Changchun, 130062, Jilin, China.
Lisai ZhuCollege of Veterinary Medicine, Jilin University, 5333 Xian Road, Changchun, 130062, Jilin, China.
Dan LiuCollege of Veterinary Medicine, Jilin University, 5333 Xian Road, Changchun, 130062, Jilin, China.
Changming GuoCollege of Veterinary Medicine, Jilin University, 5333 Xian Road, Changchun, 130062, Jilin, China.
Yue YuanCollege of Veterinary Medicine, Jilin University, 5333 Xian Road, Changchun, 130062, Jilin, China.
Chengbo ShiChangchun Institute of Biological Products Co. Ltd., 3456 Xian Road, Changchun, 130062, Jilin, China.
Zhaohui LiuChangchun Institute of Biological Products Co. Ltd., 3456 Xian Road, Changchun, 130062, Jilin, China. lzh63@163.com.
Xinping WangCollege of Veterinary Medicine, Jilin University, 5333 Xian Road, Changchun, 130062, Jilin, China. wangxp88@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis E virus (HEV) infection is an emerging disease with zoonotic transmission that represents a serious public health concern, especially in developing countries. Here we characterize a novel HEV strain CCST-517, which possesses a complete genome sequence of 7284 bp with typical HEV genome organization including 5' and 3' non-coding regions and three open reading frames. The sequence identities of CCST-517 with known HEV genotype 1, 2, 3, and 4 were 73.4-73.7, 73.2, 80.4-90.4, and 75.1-75.7%, respectively. Phylogenetic analysis clustered CCST-517 to the clade of HEV genotype 3a, together with the Japanese human HEV isolate (HE-JA10) and United States human HEV isolate (HEV-US2). Similarity plot analysis indicated that the fragment extending from 4500 to 5500 nt included evidence of one intra-genotype recombination event in the genome sequence of the CCST-517 strain. To our knowledge, this is the first report of HEV genotype 3a with its complete genome sequence revealed in China. Our findings revealed a close phylogenetic relationship of CCST-517 to human HEV-US2 and HE-JA10, implying cross-species transmission of HEV between pigs and humans.

Indexed as

GenotypeAmino Acid SequenceAnimalsBase SequenceChinaGenome, ViralHepatitis EHepatitis E virusOpen Reading FramesPhylogenyRecombination, GeneticRNA, ViralSus scrofaSwineSwine DiseasesWhole Genome SequencingRNA, ViralGenetic recombinationHepatitis EHEVPhylogenetic analysisZoonosis

Identifiers

PMID28205052

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.