ArticleTechniques in coloproctology2017
Impact of preoperative steroid or immunosuppressant use on short-term outcomes following colectomy in Crohn's disease patients.
Article in Techniques in coloproctology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease.The Cochrane database of systematic reviews · 2020Pooled it
- Influencing factors and preventive measures of infectious complications after intestinal resection for Crohn's disease.World journal of gastrointestinal surgery · 2024Article
- Systemic glucocorticoid exposure and postoperative infection risk in 143,782 appendectomy patients-a Danish longitudinal nationwide study.Langenbeck's archives of surgery · 2024Article
- Article
- When Is It Safe to Operate After Therapeutic Carpal Tunnel Injections?Hand (New York, N.Y.) · 2023Article
- Urinary manifestations in African American and Caucasian inflammatory bowel disease patients: a retrospective cohort study.BMC urology · 2022Article
- Diagnostic Accuracy of Magnetic Resonance Enterography for the Evaluation of Active and Fibrotic Inflammation in Crohn's Disease.Frontiers in surgery · 2022Article
- When should we add a diverting loop ileostomy to laparoscopic ileocolic resection for primary Crohn's disease?Surgical endoscopy · 2021Article
- Immunosuppressed Patients with Crohn's Disease Are at Increased Risk of Postoperative Complications: Results from the ACS-NSQIP Database.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- The Effects of Chronic Preoperative Steroid Therapy on Perioperative Complications Following Elective Posterior Lumbar Fusion.Global spine journal · 2018Article
- Risk of postoperative morbidity in patients having bowel resection for colonic Crohn's disease.Techniques in coloproctology · 2018Article
- Effects of glucocorticoids combined with probiotics in treating Crohn's disease on inflammatory factors and intestinal microflora.Experimental and therapeutic medicine · 2018Article
- Recent trends (2016-2017) in the treatment of inflammatory bowel disease.Annals of gastroenterological surgery · 2018Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvaluating the impact of steroid or immunosuppressants (SI) therapy prior to colectomy in Crohn's disease (CD) patients on postoperative septic and colectomy-specific outcomes using the American College of Surgeons (ACS)-National Surgical Quality Improvement Program (NSQIP)-targeted colectomy database.
methodsAll CD patients undergoing colectomy were retrieved from the 2012-2013 NSQIP-targeted database. Thirty-day postoperative outcomes were compared for patients who were on steroids or immunosuppressants (SI) within the 30 days prior to colectomy to the others using univariable and multivariable analyses.
resultsOf 2208 CD patients, 1387 (63%) were on SI. Patients in the SI group were younger, and a greater proportion underwent laparoscopic surgery (p < 0.05). SI use was associated with a higher rate of sepsis (7.6 vs. 5.2%), anastomotic leak (5.6 vs. 3.5%), and return to operating room (6.8 vs. 3.3%). On multivariable analysis, SI was associated with sepsis, septic shock, and anastomotic leak [odds ratio = 1.58, 95% confidence interval 1.09-2.27].
conclusionsThese results suggest that SI use within 30 days of colectomy is associated with a higher rate of sepsis and septic shock and anastomotic leak in CD patients. Withholding SI prior to surgery, or the selective use of an ostomy to mitigate the consequences of a leak and hence sepsis need due consideration prior to surgery.
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