Evidence map›Paper›PMID 28205033›Full record

Trial reportSurgical endoscopy2017

Midterm follow-up of a randomized trial of open surgery versus laparoscopic surgery in elderly patients with colorectal cancer.

Atsushi Ishibe, Mitsuyoshi Ota, Shoichi Fujii, Yusuke Suwa, Shinsuke Suzuki, Hirokazu Suwa, Masashi Momiyama, Jun Watanabe, Kazuteru Watanabe, Masataka Taguri and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01862562 (Randomized Controlled Trial to Evaluate Laparoscopic Versus Open Surgery in Elderly Colorectal Cancer Patients Who Were 75 Years Old or Over), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01862562 phase3unknown statusnot on this map

Randomized Controlled Trial to Evaluate Laparoscopic Versus Open Surgery in Elderly Colorectal Cancer Patients Who Were 75 Years Old or Over

TypeinterventionalSponsorShoichi Fujii, MD, PhDRan2008 to 2017Enrolled200ConditionsColorectal CancerArmsOpen surgery, Laparoscopic surgery
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Atsushi IshibeDepartment of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. a.ishibe1225@gmail.com.ORCID 0000-0002-3251-3658
Mitsuyoshi OtaDepartment of Surgery, Gastroenterological Center, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Shoichi FujiiDepartment of Surgery, Gastroenterological Center, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Yusuke SuwaDepartment of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Shinsuke SuzukiDepartment of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Hirokazu SuwaDepartment of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Masashi MomiyamaDepartment of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Jun WatanabeDepartment of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Kazuteru WatanabeDepartment of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Masataka TaguriDepartment of Biostatistics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Chikara KunisakiDepartment of Surgery, Gastroenterological Center, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Itaru EndoDepartment of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaparoscopic surgery has been widely accepted for the treatment of colorectal cancer; however, long-term outcomes in elderly patients remain controversial. The midterm results of a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer are presented.

methodsThis was a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer. The primary outcome was complication rate, and secondary outcomes included 3-year recurrence-free survival and overall survival. A total of 200 patients were randomly assigned to open surgery or laparoscopic surgery between 2008 and 2012. The main study objective was to compare the midterm outcomes of open surgery with those of laparoscopic surgery in elderly patients with colorectal cancer. This trial is registered with Clinical Trials.gov (NCT01862562).

resultsThere were no differences between the laparoscopic surgery group and open surgery group in the 3-year overall survival rate (91.5% for laparoscopic surgery vs. 90.6% for open surgery, p = 0.638) or the 3-year recurrence-free survival rate (84.8% for laparoscopic surgery vs. 88.2% for open surgery, p = 0.324). The local recurrence rate was significantly higher in the laparoscopic surgery group than in the open surgery group in rectal cancer (13.8% for laparoscopic surgery vs. 0% for open surgery, p = 0.038). In subgroup analysis according to tumor location, there were no significant differences in the 3-year overall survival rate or 3-year recurrence-free survival rate between the two treatment groups.

conclusionThe midterm outcomes of laparoscopic surgery are similar to those of open surgery in elderly patients with colorectal cancer.

Indexed as

AdenocarcinomaAgedColonColorectal NeoplasmsColorectal SurgeryFemaleFollow-Up StudiesHumansLaparoscopyMaleMiddle AgedNeoplasm Recurrence, LocalPostoperative ComplicationsRectumSurvival RateTreatment OutcomeColorectal cancerElderly patientLaparoscopic surgeryRandomized study

Identifiers

PMID28205033

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.