Evidence map›Paper›PMID 28205010›Full record

ArticleActa neuropathologica2017

Prion-specific and surrogate CSF biomarkers in Creutzfeldt-Jakob disease: diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological correlates of p-tau and Aβ42 levels.

Francesca Lattanzio, Samir Abu-Rumeileh, Alessia Franceschini, Hideaki Kai, Giulia Amore, Ilaria Poggiolini, Marcello Rossi, Simone Baiardi, Lynne McGuire, Anna Ladogana and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD.Annals of clinical and translational neurology · 2020
    Trial
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Francesca LattanzioDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Samir Abu-RumeilehDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Alessia FranceschiniDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Hideaki KaiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Giulia AmoreDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Ilaria PoggioliniDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Marcello RossiIRCCS, Institute of Neurological Sciences, Bologna, Italy.
Simone BaiardiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Lynne McGuireNational CJD Research and Surveillance Unit, University of Edinburgh, Edinburgh, Scotland, UK.
Anna LadoganaDepartment of Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
Maurizio PocchiariDepartment of Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
Alison GreenNational CJD Research and Surveillance Unit, University of Edinburgh, Edinburgh, Scotland, UK.
Sabina CapellariDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Piero ParchiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. piero.parchi@unibo.it.ORCID 0000-0002-9444-9524
University of Bologna · ITInstitute of Neurological Sciences · ITIstituto Superiore di Sanità · ITUniversity of Edinburgh · GBTohoku University · JP

Funding

Chief Scientist Office ETM/58Medical Research Council MR/J016071/1
6 · The paper itself

Abstract

The differential diagnosis of Creutzfeldt-Jakob disease (CJD) from other, sometimes treatable, neurological disorders is challenging, owing to the wide phenotypic heterogeneity of the disease. Real-time quaking-induced prion conversion (RT-QuIC) is a novel ultrasensitive in vitro assay, which, at variance with surrogate neurodegenerative biomarker assays, specifically targets the pathological prion protein (PrP

Indexed as

14-3-3 ProteinsAgedAmyloid beta-PeptidesBiomarkersBrainCreutzfeldt-Jakob SyndromeDiagnosis, DifferentialFemaleFollow-Up StudiesHumansImmunohistochemistryMaleMiddle AgedPeptide FragmentsPhosphorylationPrion Proteins14-3-3 ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersMAPT protein, humanPeptide FragmentsPrion Proteinstau ProteinsAlzheimer’s diseaseAmyloid-betaBiomarkersHuman prionsProtease-sensitive prionopathyRT-QuICTauopathy

Identifiers

PMID28205010
PMCPMC5348556
OpenAlexW2588154444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.