ArticleIntensive care medicine2017
Left ventricular systolic dysfunction during septic shock: the role of loading conditions.
Article in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06125184 (Effect of Vasopressin on Kidney and Cardiac Function in Previously Hypertensive Patients With Septic Shock), which is not on this map. Cited by 81 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Vasopressin on Kidney and Cardiac Function in Previously Hypertensive Patients With Septic Shock: A Randomized Clinical Trial
Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock: a systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- Septic cardiomyopathy: Fact or fiction?American heart journal plus : cardiology research and practice · 2026Review
- Revisiting septic cardiomyopathy: the missing role of systolic function in interpreting diastolic dysfunction and outcomes. Author's reply.Intensive care medicine · 2026Article
- Septic Cardiomyopathy in the ICU: Echocardiographic Phenotypes, Global Longitudinal Strain, and Right Ventricular Assessment.Diagnostics (Basel, Switzerland) · 2026Review
- Echocardiographic phenotypes in sepsis: identifying subgroups using latent profile analysis.Journal of intensive care · 2026Article
- Magnesium deficiency and dilated cardiomyopathy diagnosed peripartum.Obstetric medicine · 2026Review
- Effect of norepinephrine on ventricular systolic function during septic shock: the ENESySS study.Journal of anesthesia, analgesia and critical care · 2026Article
- Septic Cardiomyopathy: Age-Dependent Physiology and Hemodynamic Aspects-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Reading discordant bedside indices in sepsis-induced cardiomyopathy: an evidence-mapping framework for diagnosis and trial design.Frontiers in cardiovascular medicine · 2026Review
- Establishment and internal-external validation of a 28-day mortality prediction model for septic shock patients with left ventricular systolic dysfunction.Frontiers in medicine · 2026Article
- The role of cytokines in septic myocardial dysfunction: a translational systematic review and meta-analysis.Annals of intensive care · 2026Review
- Effects of adjunctive dobutamine on outcomes among patients with septic shock: a propensity score matching analysis.The Korean journal of internal medicine · 2025Observational
- Sepsis-Induced Cardiomyopathy and Cardiac Arrhythmias: Pathophysiology and Implications for Novel Therapeutic Approaches.Biomedicines · 2025Review
- Sepsis and the Heart: In the Quest for Noninvasive Pressure-Volume Loops at the Bedside.Critical care explorations · 2025Article
- Sepsis-induced myocardial dysfunction diagnosed with strain versus non-strain echocardiography parameters: incidence, evolution and association with prognosis.Annals of intensive care · 2025Article
- Implications of Myocardial Fibrosis Burden on Left Ventricular Systolic Function in Sepsis Survivors: Insights from a Retrospective Cohort Study Using Quantitative Late Gadolinium Enhancement Cardiovascular Magnetic Resonance.Journal of cardiovascular development and disease · 2025Article
- Article
- Left ventricular systolic longitudinal strain in mechanically ventilated patients in the intensive care unit: assessment of global and chamber reproducibility.Intensive care medicine experimental · 2025Article
- Septic Cardiomyopathy: Difficult Definition, Challenging Diagnosis, Unclear Treatment.Journal of clinical medicine · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe clinical significance of septic myocardial dysfunction is controversial, a fact that may be explained by the influence of loading conditions. Many indices may be useful to characterize cardiac function during septic shock, but their feasibility and physiological coherence in the clinical setting are unknown.
methodsHemodynamic and echocardiographic data with tissue Doppler and speckle tracking were prospectively recorded on the first 3 days of human septic shock. Hypokinesia, normokinesia, and hyperkinesia were defined as a left ventricular ejection fraction (LVEF) of <45, 45-60, and >60%, respectively. Twelve hemodynamic indices exploring contractility and loading conditions were assessed and analyzed.
resultsTwo hundred and ninety-seven echocardiographies were performed in 132 patients. During the first 24 h (H
conclusionsSpeckle tracking-derived strain was reduced in the majority of patients with septic shock, revealing covert septic myocardial dysfunction, but had poor feasibility. We found an inverse correlation between most of the contractility and afterload indices. Precise evaluation of afterload is crucial for adequate interpretation of LV systolic function in this setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.