SynthesisSchizophrenia bulletin2017
A Systematic and Meta-analytic Review of Neural Correlates of Functional Outcome in Schizophrenia.
Synthesis in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The social cognitive and neural mechanisms that underlie social functioning in individuals with schizophrenia - a review.Translational psychiatry · 2023Pooled it
- Cognitive Training and Remediation in First-Episode Psychosis: A Literature Review.Journal of the American Psychiatric Nurses AssociationPooled it
- Increased regional homogeneity modulated by metacognitive training predicts therapeutic efficacy in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021Trial
- Neural and somatic mechanisms driving clinical improvements in post-acute schizophrenia spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Longitudinal Development of Neurocognitive Functioning and Gray Matter Volume in Youths With Recurrent Psychosis Spectrum Symptoms.Schizophrenia bulletin · 2025Article
- Dysregulation of MiRNAs in schizophrenia in an Egyptian patient population.Scientific reports · 2025Article
- Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables.Schizophrenia bulletin · 2024Article
- Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods.Schizophrenia (Heidelberg, Germany) · 2024Article
- Association between urban upbringing and functional brain connectivity in schizophrenia.Indian journal of psychiatry · 2024Article
- Functional connectivity gradients of the cingulate cortex.Communications biology · 2023Article
- Impact of Cognitive Disturbances and Clinical Symptoms on Disability in Patients with Paranoid Schizophrenia: A Study of a Bulgarian Clinical Sample.International journal of environmental research and public health · 2023Article
- The Difficult Path to the Discovery of Novel Treatments in Psychiatric Disorders.Advances in neurobiology · 2023Article
- A subtype of institutionalized patients with schizophrenia characterized by pronounced subcortical and cognitive deficits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Predictive models for social functioning in healthy young adults: A machine learning study integrating neuroanatomical, cognitive, and behavioral data.Social neuroscience · 2022Article
- Cognitive and functional deficits are associated with white matter abnormalities in two independent cohorts of patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
- Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study.Molecular psychiatry · 2022Article
- Shape features of working memory-related deep-brain regions differentiate high and low community functioning in schizophrenia.Schizophrenia research. Cognition · 2022Article
- Potential diagnostic biomarkers for schizophrenia.Medical review (2021) · 2022Review
- Shared genetic influences on resting-state functional networks of the brain.Human brain mapping · 2022Article
- Complete agenesis of the corpus callosum in paranoid schizophrenia-a case report.Clinical case reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Individuals with schizophrenia are burdened with impairments in functional outcome, despite existing interventions. The lack of understanding of the neurobiological correlates supporting adaptive function in the disorder is a significant barrier to developing more effective treatments. This research conducted a systematic and meta-analytic review of all peer-reviewed studies examining brain-functional outcome relationships in schizophrenia. A total of 53 (37 structural and 16 functional) brain imaging studies examining the neural correlates of functional outcome across 1631 individuals with schizophrenia were identified from literature searches in relevant databases occurring between January, 1968 and December, 2016. Study characteristics and results representing brain-functional outcome relationships were systematically extracted, reviewed, and meta-analyzed. Results indicated that better functional outcome was associated with greater fronto-limbic and whole brain volumes, smaller ventricles, and greater activation, especially during social cognitive processing. Thematic observations revealed that the dorsolateral prefrontal cortex, anterior cingulate, posterior cingulate, parahippocampal gyrus, superior temporal sulcus, and cerebellum may have role in functioning. The neural basis of functional outcome and disability is infrequently studied in schizophrenia. While existing evidence is limited and heterogeneous, these findings suggest that the structural and functional integrity of fronto-limbic brain regions is consistently related to functional outcome in individuals with schizophrenia. Further research is needed to understand the mechanisms and directionality of these relationships, and the potential for identifying neural targets to support functional improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.