Evidence map›Paper›PMID 28204708›Full record

ArticleSchizophrenia bulletin2017

Modeling the Interplay Between Psychological Processes and Adverse, Stressful Contexts and Experiences in Pathways to Psychosis: An Experience Sampling Study.

Annelie Klippel, Inez Myin-Germeys, UnYoung Chavez-Baldini, Kristopher J Preacher, Matthew Kempton, Lucia Valmaggia, Maria Calem, Suzanne So, Stephanie Beards, Kathryn Hubbard and 10 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 5 countries.

Annelie KlippelDepartment of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Belgium.
Inez Myin-GermeysDepartment of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Belgium.
UnYoung Chavez-BaldiniDepartment of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Kristopher J PreacherPsychology & Human Development, Vanderbilt University, Nashville, TN, USA.
Matthew KemptonPsychosis Studies Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Lucia ValmaggiaPsychology Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Maria CalemPsychosis Studies Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Suzanne SoDepartment of Psychology, The Chinese University of Hong Kong, Hong Kong, China.
Stephanie BeardsCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Kathryn HubbardCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Charlotte Gayer-AndersonCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Adanna OnyejiakaPsychology Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Marieke WichersUniversity of Groningen, University Medical Centre Groningen (UMCG), University Center Psychiatry (UCP), Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), Groningen, The Netherlands.
Philip McGuirePsychosis Studies Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Robin MurrayPsychosis Studies Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Philippa GaretyPsychology Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Jim van OsDepartment of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Til WykesPsychology Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Craig MorganNational Institute for Health Research (NIHR) Mental Health Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
Ulrich ReininghausDepartment of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
King's College London · GBSouth London and Maudsley NHS Foundation Trust · GBKU Leuven · BEChinese University of Hong Kong · CNMaastricht University · NLUniversity of Groningen · NLVanderbilt University · US

Funding

Department of Health RP-PG-0606-1049Department of Health RP-PG-0612-20002Medical Research Council G0600972Medical Research Council G0700995Medical Research Council G1100583Medical Research Council MR/J008915/1Medical Research Council MR/K004867/1Medical Research Council MR/K013807/1Wellcome Trust WT087417
6 · The paper itself

Abstract

Several integrated models of psychosis have implicated adverse, stressful contexts and experiences, and affective and cognitive processes in the onset of psychosis. In these models, the effects of stress are posited to contribute to the development of psychotic experiences via pathways through affective disturbance, cognitive biases, and anomalous experiences. However, attempts to systematically test comprehensive models of these pathways remain sparse. Using the Experience Sampling Method in 51 individuals with first-episode psychosis (FEP), 46 individuals with an at-risk mental state (ARMS) for psychosis, and 53 controls, we investigated how stress, enhanced threat anticipation, and experiences of aberrant salience combine to increase the intensity of psychotic experiences. We fitted multilevel moderated mediation models to investigate indirect effects across these groups. We found that the effects of stress on psychotic experiences were mediated via pathways through affective disturbance in all 3 groups. The effect of stress on psychotic experiences was mediated by threat anticipation in FEP individuals and controls but not in ARMS individuals. There was only weak evidence of mediation via aberrant salience. However, aberrant salience retained a substantial direct effect on psychotic experiences, independently of stress, in all 3 groups. Our findings provide novel insights on the role of affective disturbance and threat anticipation in pathways through which stress impacts on the formation of psychotic experiences across different stages of early psychosis in daily life.

Indexed as

Models, StatisticalAdolescentAdultEcological Momentary AssessmentFemaleHumansMalePsychotic DisordersRiskStress, PsychologicalYoung Adultaberrant salienceat-risk mental stateexperience sampling methodfirst-episode psychosisstress sensitivitythreat anticipation

Identifiers

PMID28204708
PMCPMC5605264
OpenAlexW2588810533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.