ArticleJournal of experimental botany2017
Involvement of three putative glucosyltransferases from the UGT72 family in flavonol glucoside/rhamnoside biosynthesis in Lotus japonicus seeds.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 48 citations in OpenAlex.
- Identification and characterization of C-glycosyltransferase (CGT) gene family associated with flavonoid-mediated shelf-life extension in pearl millet flour.Functional & integrative genomics · 2026Article
- De novo biosynthesis ofBiodesign research · 2025Article
- Evolutionary dynamics and functional divergence of the UDP-glycosyltransferases gene family revealed by a pangenome-wide analysis in tomato.Horticulture research · 2025Article
- Review
- Multiprotein Complexes of Plant Glycosyltransferases Involved in Their Function and Trafficking.Plants (Basel, Switzerland) · 2025Review
- Computational-guided discovery of UDP-glycosyltransferases for lauryl glucoside production using engineered E. coli.Bioresources and bioprocessing · 2024Article
- Discovery, characterization, and comparative analysis of new UGT72 and UGT84 family glycosyltransferases.Communications chemistry · 2024Article
- Four novelHorticulture research · 2024Article
- Genome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in drought stress ofFrontiers in plant science · 2024Article
- Protein Modelling Highlighted Key Catalytic Sites Involved in Position-Specific Glycosylation of Isoflavonoids.International journal of molecular sciences · 2023Article
- PhUGT78A22, a novel glycosyltransferase in Paeonia 'He Xie', can catalyze the transfer of glucose to glucosylated anthocyanins during petal blotch formation.BMC plant biology · 2022Article
- UGT72, a Major Glycosyltransferase Family for Flavonoid and Monolignol Homeostasis in Plants.Biology · 2022Review
- Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products.Synthetic and systems biotechnology · 2022Article
- Genome-wide identification, characterization, and expression analysis of UDP-glycosyltransferase genes associated with secondary metabolism in alfalfa (Frontiers in plant science · 2022Article
- Functional Characterization of UDP-Glycosyltransferases Involved in Anti-viral Lignan Glycosides Biosynthesis inFrontiers in plant science · 2022Article
- Genome-wide analysis of UDP-glycosyltransferase gene family and identification of members involved in flavonoid glucosylation in Chinese bayberry (Frontiers in plant science · 2022Article
- N-glucosyltransferase GbNGT1 from ginkgo complements the auxin metabolic pathway.Horticulture research · 2021Article
- Dynamic Transcriptomic and Metabolomic Analyses ofFrontiers in plant science · 2021Article
- Unraveling the Glucosylation of Astringency Compounds of Horse ChestnutFrontiers in plant science · 2021Article
- Tandem UGT71B5s Catalyze Lignan Glycosylation inFrontiers in plant science · 2021Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonols are one of the largest groups of flavonoids that confer benefits for the health of plants and animals. Flavonol glycosides are the predominant flavonoids present in the model legume Lotus japonicus. The molecular mechanisms underlying the biosynthesis of flavonol glycosides as yet remain unknown in L. japonicus. In the present study, we identified a total of 188 UDP-glycosyltransferases (UGTs) in L. japonicus by genome-wide searching. Notably, 12 UGTs from the UGT72 family were distributed widely among L. japonicus chromosomes, expressed in all tissues, and showed different docking scores in an in silico bioinformatics docking analysis. Further enzymatic assays showed that five recombinant UGTs (UGT72AD1, UGT72AF1, UGT72AH1, UGT72V3, and UGT72Z2) exhibit activity toward flavonol, flavone, and isoflavone aglycones. In particular, UGT72AD1, UGT72AH1, and UGT72Z2 are flavonol-specific UGTs with different kinetic properties. In addition, the overexpression of UGT72AD1 and UGT72Z2 led to increased accumulation of flavonol rhamnosides in L. japonicus and Arabidopsis thaliana. Moreover, the increase of kaempferol 3-O-rhamnoside-7-O-rhamnoside in transgenic A. thaliana inhibited root growth as compared with the wild-type control. These results highlight the significance of the UGT72 family in flavonol glycosylation and the role of flavonol rhamnosides in plant growth.
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