ArticleEndocrinology2017
Steroid Hormones Are Key Modulators of Tissue Mechanical Function via Regulation of Collagen and Elastic Fibers.
Article in Endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Precision medicine exploration of postpartum rectus abdominis muscle separation: from basic research to clinical practice.BMC surgery · 2025Pooled it
- Spectroscopic photoacoustic imaging of cervical tissue composition in excised human samples.PloS one · 2021Trial
- Biomechanical function of the murine cervix with elastic fiber deficiency.Journal of the mechanical behavior of biomedical materials · 2026Article
- Type V Collagen Controls Decidual Extracellular Matrix Organization and Angiogenesis During Embryo Implantation.bioRxiv : the preprint server for biology · 2026Article
- Spontaneous Coronary Artery Dissection and Takotsubo Syndrome: Converging Mechanisms, Diagnostic Pitfalls, and a Unified Clinical Algorithm.Journal of clinical medicine · 2026Review
- Reprogramming the Tumor Oncobiosphere: Bioactive Nanohybrid Materials for Reversing Therapeutic Pseudo-Resistance.ACS omega · 2026Review
- The Role of Papaverine in the Molecular and Biomechanical Mechanisms of Cervical Ripening: A Narrative Review.International journal of molecular sciences · 2026Review
- Using quantitative imaging methods to investigate the association between quadriceps stiffness and knee cartilage volumes.Bone & joint research · 2026Article
- Raman spectroscopy for nondestructive detection of vaginal tissue alterations in the fibulin-5 murine model of pelvic organ prolapse.Biophotonics discovery · 2026Article
- Assessing preterm risk via label-free, multiparametric imaging of collagen fiber remodeling in the cervix.Biomedical optics express · 2026Article
- Evidence of compensatory elastin remodeling in non-prolapsed uterosacral ligaments and its divergence in histopathological subtypes of pelvic organ prolapse.BMC women's health · 2026Article
- Hippocampal tissue mechanics are sensitive to fluctuations in oestrogen across the rat oestrous cycle.Brain communications · 2026Article
- Review
- Age-related changes in quadriceps stiffness and strength: a longitudinal observation in community-dwelling older adults.BMC geriatrics · 2025Observational
- Progesterone regulation of cervix ripening in preterm and term birth in mice.Reproduction (Cambridge, England) · 2025Article
- Extracellular matrix reorganization during endometrial decidualization.Histochemistry and cell biology · 2025Article
- Fatigue loading and volumetric microscopy demonstrate changes to the mouse cervix throughout and after pregnancy.Connective tissue research · 2025Article
- Biomechanical and Compositional Changes in the Murine Uterus with Age.Annals of biomedical engineering · 2025Article
- Extracellular matrix: unlocking new avenues in cancer treatment.Biomarker research · 2025Review
- Lysyl Oxidases Are Necessary for Myometrial Contractility and On-time Parturition in Mice.Journal of the Endocrine Society · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The extracellular matrix (ECM) plays an active and dynamic role that both reflects and facilitates the functional requirements of a tissue. The mature ECM of the nonpregnant cervix is drastically reorganized during pregnancy to drive changes in tissue mechanics that ensure safe birth. In this study, our research on mice deficient in the proteoglycan decorin have led to the finding that progesterone and estrogen play distinct and complementary roles to orchestrate structural reorganization of both collagen and elastic fibers in the cervix during pregnancy. Abnormalities in collagen and elastic fiber structure and tissue mechanical function evident in the cervix of nonpregnant and early pregnant decorin-null mice transiently recover for the remainder of pregnancy only to return 1 month postpartum. Consistent with the hypothesis that pregnancy levels of progesterone and estrogen may regulate ECM organization and turnover, expressions of factors required for assembly and synthesis of collagen and elastic fibers are temporally regulated, and the ultrastructure of collagen fibrils and elastic fibers is markedly altered during pregnancy in wild-type mice. Finally, utilizing ovariectomized nonpregnant decorin-null mice, we demonstrate structural resolution of collagen and elastic fibers by progesterone or estrogen, respectively, and the potential for both ECM proteins to contribute to mechanical function. These investigations advance understanding of regulatory factors that drive specialized ECM organization and contribute to an understanding of the cervical remodeling process, which may provide insight into potential complications associated with preterm birth that impact 9.6% of live births in the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.