ArticleCerebral cortex (New York, N.Y. : 1991)2018
Geometric Navigation of Axons in a Cerebral Pathway: Comparing dMRI with Tract Tracing and Immunohistochemistry.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Heterogeneity of White Matter Structure in the Human Brain.Research square · 2026Article
- Heterogeneity of white-matter organization in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Association Between Changes in White Matter Volume Detected With Diffusion Tensor-Based Morphometry and Motor Recovery After Stroke.Neurology · 2025Article
- Article
- Anatomically informed multi-level fiber tractography for targeted virtual dissection.Magma (New York, N.Y.) · 2023Article
- Article
- Scan-rescan repeatability of axonal imaging metrics using high-gradient diffusion MRI and statistical implications for study design.NeuroImage · 2021Article
- Hodology of the superior longitudinal system of the human brain: a historical perspective, the current controversies, and a proposal.Brain structure & function · 2021Review
- Tracking the Corticospinal Tract in Patients With High-Grade Glioma: Clinical Evaluation of Multi-Level Fiber Tracking and Comparison to Conventional Deterministic Approaches.Frontiers in oncology · 2021Article
- Cognitive and Emotional Mapping With SEEG.Frontiers in neurology · 2021Review
- Axon diameter index estimation independent of fiber orientation distribution using high-gradient diffusion MRI.NeuroImage · 2020Article
- Protection of axonal integrity with 48 or 72 h of cerebral hypothermia in near-term fetal sheep.Pediatric research · 2020Article
- Evolution of Brain Connections: Integrating Diffusion MR Tractography With Gene Expression Highlights Increased Corticocortical Projections in Primates.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Looking through Brains with Fast Passive CLARITY: Zebrafish, Rodents, Non-human Primates and Humans.Bio-protocol · 2019Article
- Parallel trends in cortical gray and white matter architecture and connections in primates allow fine study of pathways in humans and reveal network disruptions in autism.PLoS biology · 2018Article
- Childhood Emotional Abuse Moderates Associations Among Corticomotor White Matter Structure and Stress Neuromodulators in Women With and Without Depression.Frontiers in neuroscience · 2018Article
- The Nomenclature of Human White Matter Association Pathways: Proposal for a Systematic Taxonomic Anatomical Classification.Frontiers in neuroanatomy · 2018Review
- The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and Striatum.Frontiers in neuroanatomy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Brain fiber pathways are presumed to follow smooth curves but recent high angular resolution diffusion MRI (dMRI) suggests that instead they follow 3 primary axes often nearly orthogonal. To investigate this, we analyzed axon pathways under monkey primary motor cortex with (1) dMRI tractography, (2) axon tract tracing, and (3) axon immunohistochemistry. dMRI tractography shows the predicted crossings of axons in mediolateral and dorsoventral orientations and does not show axon turns in this region. Axons labeled with tract tracer in the motor cortex dispersed in the centrum semiovale by microscopically sharp axonal turns and/or branches (radii ≤15 µm) into 2 sharply defined orientations, mediolateral and dorsoventral. Nearby sections processed with SMI-32 antibody to label projection axons and SMI-312 antibody to label all axons revealed axon distributions parallel to the tracer axons. All 3 histological methods confirmed preponderant axon distributions parallel with dMRI axes with few axons (<20%) following smooth curves or diagonal orientations. These findings indicate that axons navigate deep white matter via microscopic sharp turns and branches between primary axes. They support dMRI observations of primary fiber axes, as well as the prediction that fiber crossings include navigational events not yet directly resolved by dMRI. New methods will be needed to incorporate coherent microscopic navigation into dMRI of connectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.