ReviewInterventional medicine & applied science2016
Effects of aqueous extract of alfalfa on hyperglycemia and dyslipidemia in alloxan-induced diabetic Wistar rats.
Review in Interventional medicine & applied science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Eicosapentaenoic acid ethyl ester, cardiac metabolomic and lipidomic signatures, and cardioprotection in myocardial infarction.European heart journal · 2026Article
- Muscle Metabolomic Responses of Dumont and Mongolian Sheep to Alfalfa Hay- and Corn Straw-Based Diets: An Untargeted Metabolomics Study.Animals : an open access journal from MDPI · 2026Article
- Protective Effect ofCurrent diabetes reviews · 2026Article
- Gastroprotective evaluation ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Trans-differentiation of mouse mesenchymal stem cells into pancreatic β-like cells by a traditional anti-diabetic medicinal herbJournal of traditional and complementary medicine · 2022Article
- Hypoglycemic, hepatoprotective, and hypolipidemic effects of hydroalcoholic extract ofResearch in pharmaceutical sciences · 2021Article
- Protective Effects of Anthocyanin Extract from Purple Sweet Potato (Preventive nutrition and food science · 2020Article
- Ultrasound-enhanced gene delivery to alfalfa cells by hPAMAM dendrimer nanoparticles.Turkish journal of biology = Turk biyoloji dergisi · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the effects of aqueous extract of alfalfa on blood glucose and serum lipids in alloxan-induced diabetic rats. MATERIALS AND
methodsThirty-two adult male Wistar rats weighing 210-250 g were selected and divided randomly into four groups of eight animals each for 21 days as follows: (1) control group, (2) diabetic control group, (3) diabetic group plus aqueous extract of alfalfa (250 mg/l), and (4) diabetic group plus aqueous extract of alfalfa (500 mg/l). Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), very low-density lipoprotein (VLDL), glucose, and the liver enzymes such as aspartate transaminase (AST) and alanine transaminase (ALT) were measured at the end of period in all studied groups.
resultsAdministration of 250 and 500 mg/l aqueous alfalfa extract resulted in a significantly decreased glucose, TC, TG, LDL-C, VLDL, ALT, and AST levels and increased HDL levels as compared with the control group and diabetic control group (
conclusionThese results suggest that aqueous alfalfa extract revealed significant effects on blood lipids and glucose levels in diabetic rats and might be useful in prevention and treatment of diabetes. However, further studies are needed to determine the exact impacts of those effects.
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