Evidence map›Paper›PMID 28203182›Full record

ArticleCase reports in neurology

Treatable Leukoencephalopathy in a Patient with Hypophosphatemia.

Masahiro Okazaki, Makito Hirano, Tomoki Iwatsu, Masaki Yamana, Hidekazu Suzuki, Takao Satou, Susumu Kusunoki

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Osmotic demyelination syndrome and leukoencephalopathy in FGF23-related hypophosphatemia: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Masahiro OkazakiDepartment of Neurology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Makito HiranoDepartment of Neurology, Kindai University Faculty of Medicine, Osakasayama, Japan; Department of Neurology, Sakai Hospital Kindai University Faculty of Medicine, Sakai, Japan.
Tomoki IwatsuDepartment of Neurology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Masaki YamanaDepartment of Neurology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Hidekazu SuzukiDepartment of Neurology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Takao SatouDepartment of Pathology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Susumu KusunokiDepartment of Neurology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Kindai University · JPKindai University Sakai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the first patient with pathologically proven leukoencephalopathy associated with hypophosphatemia. A 61-year-old woman had repetitive episodes of decreased consciousness with pontine and pallidal lesions and extensive leukoencephalopathy on MRI, later found to be associated with hypophosphatemia. Although hypophosphatemia has been linked to central pontine and extrapontine myelinolysis (osmotic myelinolysis), lesions in the deep white matter have not been reported. Brain biopsy performed during the first diagnosis process revealed nonspecific demyelination with gliosis, a finding similar to that of chronic osmotic myelinolysis. After normalization of phosphate levels, her consciousness completely improved and MRI abnormalities partly resolved. We should consider that leukoencephalopathy can be associated with hypophosphatemia, which is often treatable.

Indexed as

Decreased phosphate levelHypophosphatemiaLeukoencephalopathyOsmotic myelinolysisPhosphate binder

Identifiers

PMID28203182
PMCPMC5260535
OpenAlexW2567301211

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.