ArticleFrontiers in behavioral neuroscience2017
Gene-Gene-Environment Interactions of Serotonin Transporter, Monoamine Oxidase A and Childhood Maltreatment Predict Aggressive Behavior in Chinese Adolescents.
Article in Frontiers in behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Context-dependent interaction between oxytocin gene polymorphisms and alcohol dependence in modulating negative emotions during acute alcohol withdrawal in adult males.Frontiers in psychiatry · 2026Article
- Factors associated with violent offenders with mental illness in forensic psychiatric evaluations.PloS one · 2025Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- The Role of Serotonergic Gene Methylation in Regulating Anxiety-Related Personality Traits in Chimpanzees.Biology · 2022Article
- The Interaction BetweenFrontiers in psychiatry · 2022Article
- Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin.Scientific reports · 2021Article
- Alcohol, Aggression, and Violence: From Public Health to Neuroscience.Frontiers in psychology · 2021Review
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Methylation of theAnnals of translational medicine · 2020Article
- Effects of BDNF Val66Met polymorphisms on brain structures and behaviors in adolescents with conduct disorder.European child & adolescent psychiatry · 2020Article
- B-Cell Receptor-Associated Protein 31 Negatively Regulates the Expression of Monoamine Oxidase AFrontiers in molecular biosciences · 2020Article
- Understanding the Scientific Basis of Post-traumatic Stress Disorder (PTSD): Precision Behavioral Management Overrides Stigmatization.Molecular neurobiology · 2019Review
- Family structure, birth order, and aggressive behaviors among school-aged boys with attention deficit hyperactivity disorder (ADHD).Social psychiatry and psychiatric epidemiology · 2019Article
- MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli.Scientific reports · 2019Article
- Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- MAOA genotype influences neural response during an inhibitory task in adolescents with conduct disorder.European child & adolescent psychiatry · 2018Article
- Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: traditional (Hadza and Datoga) and industrial (Russians) populations compared.Journal of physiological anthropology · 2018Article
- Interacting Effect of Catechol-Frontiers in psychology · 2018Article
- Addressing Emotional Dysregulation and Potential Pharmacogenetic Implication of 5-HTTLPR Genotype in Attention Deficit Hyperactivity Disorder.Complex psychiatryReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene-environment interactions that moderate aggressive behavior have been identified independently in the serotonin transporter (5-HTT) gene and monoamine oxidase A gene (MAOA). The aim of the present study was to investigate epistasis interactions between MAOA-variable number tandem repeat (VNTR), 5-HTTlinked polymorphism (LPR) and child abuse and the effects of these on aggressive tendencies in a group of otherwise healthy adolescents. A group of 546 Chinese male adolescents completed the Child Trauma Questionnaire and Youth self-report of the Child Behavior Checklist. Buccal cells were collected for DNA analysis. The effects of childhood abuse, MAOA-VNTR, 5-HTTLPR genotypes and their interactive gene-gene-environmental effects on aggressive behavior were analyzed using a linear regression model. The effect of child maltreatment was significant, and a three-way interaction among MAOA-VNTR, 5-HTTLPR and sexual abuse (SA) relating to aggressive behaviors was identified. Chinese male adolescents with high expression of the MAOA-VNTR allele and 5-HTTLPR "SS" genotype exhibited the highest aggression tendencies with an increase in SA during childhood. The findings reported support aggression being a complex behavior involving the synergistic effects of gene-gene-environment interactions.
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