ArticleJournal of pain research2017
Proton magnetic resonance spectroscopy assessment of metabolite status of the anterior cingulate cortex in chronic pain patients and healthy controls.
Article in Journal of pain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Altered Brain Functional Connectivity and Neurometabolite Correlations in Orofacial Chronic Pain with Central Sensitization.Journal of pain research · 2025Article
- Alterations in metabolites in the anterior cingulate cortex and thalamus and their associations with pain and empathy in patients with chronic mild pain: a preliminary study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Chronic neuropathic pain components in whiplash-associated disorders correlate with metabolite concentrations in the anterior cingulate and dorsolateral prefrontal cortex: a consensus-driven MRS re-examination.Frontiers in medicine · 2024Article
- Neurometabolite alterations in traumatic brain injury and associations with chronic pain.Frontiers in neuroscience · 2023Article
- Altered spontaneous brain activity patterns in patients with diabetic retinopathy using amplitude of low-frequency fluctuation.World journal of diabetes · 2022Article
- Neurometabolite Levels and Relevance to Central Sensitization in Chronic Orofacial Pain Patients: A Magnetic Resonance Spectroscopy Study.Journal of pain research · 2022Article
- Reactive Astrocytes: Critical Players in the Development of Chronic Pain.Frontiers in psychiatry · 2021Review
- Metabolite activity in the anterior cingulate cortex during a painful stimulus using functional MRS.Scientific reports · 2020Article
- Could Dietary Glutamate Play a Role in Psychiatric Distress?Neuropsychobiology · 2020Review
- Cingulate glutamate levels associate with pain in chronic pancreatitis patients.NeuroImage. Clinical · 2019Article
- Peripheral and Central Metabolites Affecting Depression, Anxiety, Suicidal Ideation, and Anger in Complex Regional Pain Syndrome Patients Using a Magnetic Resonance Spectroscopy: A Pilot Study.Psychiatry investigation · 2018Article
- Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism.BMC pharmacology & toxicology · 2018Article
- The effects of transcranial direct current stimulation on metabolite changes at the anterior cingulate cortex in neuropathic pain: a pilot study.Journal of pain research · 2018Article
- Relationships between brain metabolite levels, functional connectivity, and negative mood in urologic chronic pelvic pain syndrome patients compared to controls: A MAPP research network study.NeuroImage. Clinical · 2018Article
- Neurotransmitter alterations in the anterior cingulate cortex in Crohn's disease patients with abdominal pain: A preliminary MR spectroscopy study.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic pain is a common cause of reduced quality of life. Recent studies suggest that chronic pain patients have a different brain neurometabolic status to healthy people. Proton magnetic resonance spectroscopy ( PATIENTS AND
methodsWe recruited 56 chronic pain patients and 60 healthy controls to compare brain metabolic characteristics. The concentrations of glutamic acid (Glu), myo-inositol (Ins),
resultsOur analysis indicates that pain patients have statistically significantly higher levels of Glu/tCr (
conclusionChronic pain patients have a different metabolite status in the anterior cingulate cortex to controls. Within the pain patient group, HADS scores had a positive relationship with NAA/tCr and Glx/tCr levels.
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