Evidence map›Paper›PMID 28202791›Full record

ReviewJournal of clinical microbiology2017

Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard.

Shawn R Lockhart, Mahmoud A Ghannoum, Barbara D Alexander

Abstract readReview
In one paragraph

Review in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pathogens (Basel, Switzerland) · 2024
    Pooled it
  3. Antimicrobial agents and chemotherapy · 2026
    Article
  4. Establishment of epidemiological cutoff values againstJournal of clinical microbiology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Establishment of epidemiological cutoff values forJournal of clinical microbiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Clinics and practice · 2024
    Article
  17. Uncovering a NovelJournal of fungi (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shawn R LockhartMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA gyi2@cdc.gov.
Mahmoud A GhannoumCenter for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
Barbara D AlexanderDivision of Infectious Diseases and International Health, Departments of Medicine and Pathology, Duke University, Durham, North Carolina, USA.

Funding

Mechanism of antifungal action of Pichia proteinsR01DE024228 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI GHANNOUM, MAHMOUD A · 2014 to 2018
$2.0M
Low-Dose High-Resolution Dental RadiographyR44DE017846 · NIDCR · DXRAY, INC. · PI HARTSOUGH, NEAL EUGENE · 2010 to 2011
$1.1M
Low-Dose High-Resolution Dental RadiographyR43DE017846 · NIDCR · DXRAY, INC. · PI HARTSOUGH, NEAL EUGENE · 2007 to 2007
$198k
NIDCR NIH HHS R01 DE024228NIDCR NIH HHS R43 DE017846NIDCR NIH HHS R44 DE017846
6 · The paper itself

Abstract

Breakpoints are used to predict whether an antifungal agent will be clinically effective against a particular fungal isolate. They are based on a combination of MIC values, pharmacokinetic/pharmacodynamic values, and clinical outcome data. For many fungus-antifungal combinations, these data might never be available. For these combinations, epidemiological cutoff values (ECVs) provide a methodology for categorizing isolates as either wild type (WT) or non-WT. In this review, we define ECVs, explain how they are generated using the CLSI methodology in standard M57, and describe how they can be used in clinical practice.

Indexed as

Antifungal AgentsCandida glabrataCandidiasisCryptococcosisCryptococcus neoformansDrug Resistance, FungalHumansMicrobial Sensitivity TestsTreatment OutcomeAntifungal AgentsbreakpointECVepidemiological cutoff value

Identifiers

PMID28202791
PMCPMC5405245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.