ArticleScience translational medicine2017
Nodding syndrome may be an autoimmune reaction to the parasitic worm
3 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 80 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
13.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis
Safety and Efficacy of Combination Therapy With Ivermectin, Diethylcarbamazine, and Albendazole (IDA) for Individuals With Onchocerciasis
NCT06070116 phase2active not recruitingnot on this mapstarted 2024, after this paper: background citation
Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis
Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?PLoS neglected tropical diseases · 2021Pooled it
- Doxycycline for the treatment of nodding syndrome: a randomised, placebo-controlled, phase 2 trial.The Lancet. Global health · 2024Trial
- Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial.PLoS neglected tropical diseases · 2020Trial
- Setting up a clinical trial for a novel disease: a case study of the Doxycycline for the Treatment of Nodding Syndrome Trial - challenges, enablers and lessons learned.Global health action · 2018Trial
- Risk of adverse pregnancy outcomes following inadvertent exposure to ivermectin during the periconception period: findings from two cluster-randomized trials in Mozambique and Kenya.EClinicalMedicine · 2026Article
- From parasite-induced immune activation to neuroinflammation and behavioral dysfunction: convergent mechanisms across protozoa and helminths: a review.Journal of neuroinflammation · 2026Review
- Article
- Onchocerciasis overview: pathogenesis, clinical spectrum, and therapeutic challenges of a neglected tropical disease.Frontiers in parasitology · 2026Review
- The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggeredFrontiers in molecular neuroscience · 2026Article
- Investigating HLA haplotypes as a potential risk factor for nodding syndrome: A case-control study in the Mahenge area, Tanzania.PLoS neglected tropical diseases · 2025Article
- Molecular Mimicry Drives Locally Produced Autoantibodies in Subarachnoid Neurocysticercosis.Open forum infectious diseases · 2025Article
- Enigmatic intractable Epilepsy patients have antibodies that bind glutamate receptor peptides, kill neurons, damage the brain, and cause Generalized Tonic Clonic Seizures.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Nodding syndrome is unlikely to be an autoimmune reaction to leiomodin-1 after infection byBiochemistry and biophysics reports · 2023Article
- The tau hypothesis of nodding syndrome in Africa.PLoS neglected tropical diseases · 2023Article
- Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns.PLoS neglected tropical diseases · 2023Article
- Excitatory amino acids, possible causative agents of nodding syndrome in eastern Africa.Tropical medicine and health · 2023Article
- Onchocerciasis-associated epilepsy in Maridi, South Sudan: Modelling and exploring the impact of control measures against river blindness.PLoS neglected tropical diseases · 2023Article
- Genomic analysis, immunomodulation and deep phenotyping of patients with nodding syndrome.Brain : a journal of neurology · 2023Article
- The spectrum of disease and tau pathology of nodding syndrome in Uganda.Brain : a journal of neurology · 2023Article
- Comparison of Structural Changes in Nodding Syndrome and Other Epilepsies Associated WithNeurology(R) neuroimmunology & neuroinflammation · 2023Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 2 countries.
Tory P JohnsonSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7468-3586
Richa TyagiSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-3627-1972
Paul R LeeSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-0402-386X
Myoung-Hwa LeeSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-8546-8272
Kory R JohnsonBioinformatics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7678-3812
Jeffrey KowalakClinical Proteomics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2758-438X
Abdel ElkahlounMicroarray Core Facility, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7085-0762
Marie MedynetsNeural Differentiation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Alina HateganSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Joseph KubofcikHelminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8167-0230
James SejvarDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.ORCID 0000-0002-2536-3276
Jeffrey RattoDivision of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Sudhir BungaDivision of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Issa MakumbiMinistry of Health, Kampala, Uganda.ORCID 0000-0003-3579-2485
Jane R AcengMinistry of Health, Kampala, Uganda.
Thomas B NutmanHelminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6887-4941
Scott F DowellBill & Melinda Gates Foundation, Seattle, WA 98109, USA.ORCID 0000-0002-3878-5056
Avindra NathSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. natha@ninds.nih.gov.ORCID 0000-0003-0927-5855
National Institutes of Health · USCenters for Disease Control and Prevention · USMinistry of Health · UGNational Institute of Allergy and Infectious Diseases · USNational Institute of Neurological Disorders and Stroke · USGates Foundation · USNational Human Genome Research Institute · US
Funding
Neuropathogenesis of Retroviral InfectionsZIANS003130 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2011 to 2025
$73.7MClinical And Therapeutic Studies Of Human Filariasis and Related DiseasesZIAAI000439 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$14.8MNHGRI/DIR Microarray CoreZICHG200365 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ELKAHLOUN, ABDEL · 2011 to 2025
$9.0MNINDS Clinical Proteomics UnitZICNS003147 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI KOWALAK, JEFFREY · 2016 to 2023
$4.9MIntramural CDC HHS CC999999
Abstract
Nodding syndrome is an epileptic disorder of unknown etiology that occurs in children in East Africa. There is an epidemiological association with
Indexed as
Amino Acid SequenceAnimalsAutoantibodiesAutoantigensAutoimmune DiseasesCentral Nervous SystemChildChild, PreschoolCross ReactionsCytoskeletal ProteinsFemaleHelminth ProteinsHumansMaleNodding SyndromeOnchocerca volvulusAutoantibodiesAutoantigensCytoskeletal ProteinsHelminth ProteinsLMOD1 protein, human
Identifiers
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Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.