ArticleScience translational medicine2017
Delayed differentiation of potent effector CD8
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Initiation of Antiretroviral Therapy during Primary HIV Infection: Effects on the Latent HIV Reservoir, Including on Analytic Treatment Interruptions.AIDS reviews · 2020Pooled it
- Trial
- Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection.The Journal of infectious diseases · 2022Trial
- Patterns of pretreatment drug resistance mutations of very early diagnosed and treated infants in Botswana.AIDS (London, England) · 2021Trial
- Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption.Nature medicine · 2020Trial
- Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection.Science translational medicine · 2019Trial
- Early intervention, lasting impact: benefits of early antiretroviral therapy and implications for posttreatment control.Current opinion in HIV and AIDS · 2026Review
- Recapitulating the qualities of HIV-specific CD8 + T cells from spontaneous controllers.Current opinion in HIV and AIDS · 2026Review
- Article
- GITR triggering has limited impact on HIV-specific CD8 T-cell function but enhances HIV transcription reactivation from latently infected CD4 T-cells.Scientific reports · 2025Article
- Acute HIV Infection and ART Response: Insights into T Cell Subsets, Activation, Exhaustion, and Blood and GALT HIV Reservoir.Viruses · 2025Article
- Dynamic changes in immune cell subsets in blood and lymph node over the course of acute HIV infection.Journal of virus eradication · 2025Article
- Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells.JCI insight · 2025Article
- Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion.PLoS pathogens · 2024Article
- Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure.Nature reviews. Microbiology · 2024Review
- Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion.bioRxiv : the preprint server for biology · 2024Article
- Cohort Profile: The Zurich Primary HIV Infection Study.Microorganisms · 2024Article
- Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8Nature communications · 2024Article
- Epitope-dependent effect of long-term cART on maintenance and recovery of HIV-1-specific CD8Journal of virology · 2023Article
- An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8Cell host & microbe · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
24 authors at 11 institutions in 5 countries.
Hiroshi TakataU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-1457-6919
Supranee BuranapraditkunU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Cari KessingThe Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0003-1315-9734
James L K FletcherSEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Roshell MuirDepartment of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
Virginie TardifDepartment of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.ORCID 0000-0001-5604-6524
Pearline CartwrightSchool of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Claire VandergeetenVaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
Wendy BakemanVaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.ORCID 0000-0002-5350-7150
Carmen N NicholsVaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.ORCID 0000-0001-7949-2455
Suteeraporn PinyakornU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-3880-4381
Pokrath HansasutaFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Eugene KroonSEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Thep ChalermchaiSEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Robert O'ConnellArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Jerome KimInternational Vaccine Institute, Seoul, Republic of Korea.ORCID 0000-0003-0461-6438
Nittaya PhanuphakSEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Merlin L RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-3949-9649
Nelson L MichaelU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-5882-5548
Nicolas ChomontDepartment of Microbiology, Infectiology, and Immunology, Centre de Recherche Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Quebec, Canada.
Elias K HaddadDepartment of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.ORCID 0000-0002-4537-8301
Jintanat AnanworanichU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Lydie TrautmannU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. ltrautmann@hivresearch.org.ORCID 0000-0002-3012-0009
RV254/SEARCH010 and the RV304/SEARCH013 Study Groups
Henry M. Jackson Foundation · USThai Red Cross Society · THDrexel University · USVaccine & Gene Therapy Institute of Florida · USArmed Forces Research Institute of Medical Science · THCase Western Reserve University · USCentre Hospitalier de l’Université de Montréal · CAChulalongkorn University · THInternational Vaccine Institute · KRScripps Research Institute · USWalter Reed Army Institute of Research · US
Funding
MOLECULAR BASIS OF VIRAL PATHOGENESIST32AI007354 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 1989 to 2020
$5.2MPreservation of adaptive immunity leads to HIV control upon treatment cessation.R01AI108433 · NIAID · VGTI FLORIDA · PI VASAN, SANDHYA · 2014 to 2018
$3.6MNIAID NIH HHS R01 AI108433NIAID NIH HHS T32 AI007354
Abstract
CD8
Indexed as
Cell DifferentiationAcute DiseaseAdultAntiretroviral Therapy, Highly ActiveCD8-Positive T-LymphocytesCell ProliferationCytokinesDisease ReservoirsFemaleHIV InfectionsHumansMaleSurvival AnalysisViral LoadViremiaCytokines
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.