Evidence map›Paper›PMID 28202761›Full record

ArticleJournal of virology2017

The Long Noncoding RNA NEAT1 Exerts Antihantaviral Effects by Acting as Positive Feedback for RIG-I Signaling.

Hongwei Ma, Peijun Han, Wei Ye, Hesong Chen, Xuyang Zheng, Linfeng Cheng, Liang Zhang, Lan Yu, Xing'an Wu, Zhikai Xu and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 179 citations in OpenAlex.

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  8. Labeling of Long Noncoding RNAs to Study Virus-Induced Nuclear Aggregates.Methods in molecular biology (Clifton, N.J.) · 2026
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  20. The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Hongwei MaDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Peijun HanDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Wei YeDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Hesong ChenDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Xuyang ZhengCenter of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Linfeng ChengDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Liang ZhangDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Lan YuDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Xing'an WuDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Zhikai XuDepartment of Microbiology, Fourth Military Medical University, Xi'an, China.
Yingfeng LeiDepartment of Microbiology, Fourth Military Medical University, Xi'an, China yflei@fmmu.edu.cn flzhang@fmmu.edu.cn.
Fanglin ZhangDepartment of Microbiology, Fourth Military Medical University, Xi'an, China yflei@fmmu.edu.cn flzhang@fmmu.edu.cn.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hantavirus infection, which causes zoonotic diseases with a high mortality rate in humans, has long been a global public health concern. Over the past decades, accumulating evidence suggests that long noncoding RNAs (lncRNAs) play key regulatory roles in innate immunity. However, the involvement of host lncRNAs in hantaviral control remains uncharacterized. In this study, we identified the lncRNA NEAT1 as a vital antiviral modulator. NEAT1 was dramatically upregulated after Hantaan virus (HTNV) infection, whereas its downregulation

Indexed as

A549 CellsAnimalsCell Line, TumorChlorocebus aethiopsDEAD Box Protein 58DEAD-box RNA HelicasesHantaan virusHantavirus InfectionsHEK293 CellsHeLa CellsHumansHuman Umbilical Vein Endothelial CellsImmunity, InnateInterferon-betaMaleMiceDDX60 protein, humanDEAD Box Protein 58DEAD-box RNA HelicasesInterferon-betaNEAT1 long non-coding RNA, humanPTB-Associated Splicing FactorReceptors, ImmunologicRIGI protein, humanRNA, Long NoncodingRNA, Small Interferingbeta interferonDDX60Hantaan virusinnate immunityinterferonslong noncoding RNANEAT1RIG-ISFPQ

Identifiers

PMID28202761
PMCPMC5391460
OpenAlexW2587820129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.