ReviewJournal of the Royal Society, Interface2017
Control and regulation of pathways via negative feedback.
Review in Journal of the Royal Society, Interface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Finerenone Dose-Exposure-Serum Potassium Response Analysis of FIDELIO-DKD Phase III: The Role of Dosing, Titration, and Inclusion Criteria.Clinical pharmacokinetics · 2022Trial
- Article
- The return of metabolism: biochemistry and physiology of glycolysis.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Controlling unwanted memories: A conceptual review grounded in the process model of emotion regulation.Psychonomic bulletin & review · 2025Review
- Molecular Insights Into the Interaction of Tryptophan Metabolites With Tryptophan and Indoleamine 2,3-Dioxygenases: Nitric Oxide a New Effector of Tryptophan 2,3-Dioxygenase and Their Roles in Infection.International journal of tryptophan research : IJTR · 2025Article
- Design patterns of biological cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Unravelling metabolic cross-feeding in a yeast-bacteria community usingMolecular systems biology · 2023Article
- Control Analysis of Cooperativity and Complementarity in Metabolic Regulations: The Case of NADPH Homeostasis.Metabolites · 2023Article
- Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy.PLoS biology · 2022Article
- Dynamics and Sensitivity of Signaling Pathways.Current pathobiology reports · 2022Article
- Combined Transcriptomic and Protein Array Cytokine Profiling of Human Stem Cells from Dental Apical Papilla Modulated by Oral Bacteria.International journal of molecular sciences · 2022Article
- Principles of Endocrine Regulation: Reconciling Tensions Between Robustness in Performance and Adaptation to Change.Frontiers in endocrinology · 2022Article
- Metabolic buffer analysis reveals the simultaneous, independent control of ATP and adenylate energy ratios.Journal of the Royal Society, Interface · 2021Article
- Seeing the forest for the trees: Retrieving plant secondary biochemical pathways from metabolome networks.Computational and structural biotechnology journal · 2021Review
- Article
- Understanding biochemical design principles with ensembles of canonical non-linear models.PloS one · 2020Article
- Optimal control of bacterial growth for the maximization of metabolite production.Journal of mathematical biology · 2019Article
- Towards feedback-controlled nanomedicines for smart, adaptive delivery.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Tellurium: An extensible python-based modeling environment for systems and synthetic biology.Bio Systems · 2018Article
- Machine Learning Methods for Analysis of Metabolic Data and Metabolic Pathway Modeling.Metabolites · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The biochemical networks found in living organisms include a huge variety of control mechanisms at multiple levels of organization. While the mechanistic and molecular details of many of these control mechanisms are understood, their exact role in driving cellular behaviour is not. For example, yeast glycolysis has been studied for almost 80 years but it is only recently that we have come to understand the systemic role of the multitude of feedback and feed-forward controls that exist in this pathway. In this article, control theory is discussed as an approach to dissect the control logic of complex pathways. One of the key issues is distinguishing between the terms control and regulation and how these concepts are applied to regulated enzymes such as phosphofructokinase. In doing so, one of the paradoxes in metabolic regulation can be resolved where enzymes such as phosphofructokinase have little control but, nevertheless, possess significant regulatory influence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.