Evidence map›Paper›PMID 28202537›Full record

ArticleGenes & development2017

In search of the mechanism that shapes the neutrophil's nucleus.

Katia Georgopoulos

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Katia GeorgopoulosCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

Funding

The Next Generation Immunoanalysis CoreP30AR069625 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN · 2016 to 2025
$8.8M
Role of IKAROS in the Biology and Therapy of High-Risk Precursor B-Cell LeukemiaR01CA190964 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GEORGOPOULOS, KATIA, VAN ETTEN, RICHARD A. · 2015 to 2019
$2.7M
Ikaros-based epigenetic regulation of T cell leukemogenesisR01CA158006 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI GEORGOPOULOS, KATIA · 2012 to 2016
$2.0M
Epigenetic regulation of proinflammatory responses in the skinR01AR069132 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI GEORGOPOULOS, KATIA · 2016 to 2020
$1.8M
Ikaros regulation: study on hemo-lymphopoiesisR01CA162092 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI GEORGOPOULOS, KATIA · 2011 to 2015
$1.8M
Mechanisms of human pre-B cell differentiationR21AI124326 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI GEORGOPOULOS, KATIA · 2016 to 2017
$450k
NCI NIH HHS R01 CA158006NCI NIH HHS R01 CA162092NCI NIH HHS R01 CA190964NIAID NIH HHS R21 AI124326NIAMS NIH HHS P30 AR069625NIAMS NIH HHS R01 AR069132
6 · The paper itself

Abstract

The organization of the genome within the confines of the nuclear compartment is considered a key contributor to transcription and DNA replication, repair, and recombination. A typical higher eukaryotic cell has a spherical nucleus that is ∼10 µm in diameter. This is not the case for a neutrophil, a short-lived innate immune cell with an unusual multilobular nuclear structure that may serve purposes outside nuclear functions. In this issue of

Indexed as

Cell NucleusDNA ReplicationGenomeHumansNeutrophilsgenome topologyLamin B receptorneutrophilsnucleolirDNA

Identifiers

PMID28202537
PMCPMC5322735

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.