Evidence map›Paper›PMID 28202528›Full record

ArticleCancer research2017

Distinct Levels of Radioresistance in Lgr5

Guoqiang Hua, Chu Wang, Yan Pan, Zhaoshi Zeng, Sang Gyu Lee, Maria Laura Martin, Adriana Haimovitz-Friedman, Zvi Fuks, Philip B Paty, Richard Kolesnick

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 54 citations in OpenAlex.

  1. Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Review
  3. Article
  4. Anti-Ceramide ScFv Prophylaxis for First Responders to a Limited Nuclear Attack.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2022
    Article
  12. Article
  13. Article
  14. Frontiers in nutrition · 2022
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Guoqiang HuaInstitute of Radiation Medicine, Fudan University, Shanghai, China. r-kolesnick@ski.mskcc.org guoqianghua@fudan.edu.cn.
Chu WangInstitute of Radiation Medicine, Fudan University, Shanghai, China.
Yan PanInstitute of Radiation Medicine, Fudan University, Shanghai, China.
Zhaoshi ZengDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Sang Gyu LeeLaboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York.
Maria Laura MartinLaboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York.
Adriana Haimovitz-FriedmanDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Zvi FuksDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Philip B PatyDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Richard KolesnickLaboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York. r-kolesnick@ski.mskcc.org guoqianghua@fudan.edu.cn.
Memorial Sloan Kettering Cancer Center · USFudan University · CN

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Although small and large intestines possess seemingly similar Wnt-driven leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5)

Indexed as

AnimalsColonIn Situ HybridizationIntestinal MucosaIntestine, SmallMiceMice, Inbred C57BLMice, TransgenicRadiation ToleranceReceptors, G-Protein-CoupledStem CellsWhole-Body IrradiationLgr5 protein, mouseReceptors, G-Protein-Coupled

Identifiers

PMID28202528
PMCPMC5621135
OpenAlexW2587802703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.