ArticleThe Journal of experimental medicine2017
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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57 citing papers in PubMed, 82 citations in OpenAlex.
- Loss of TCA cycle turning promotes stem cell function.bioRxiv : the preprint server for biology · 2026Article
- RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis.Science advances · 2026Article
- Mitochondria: the key hub for hematopoietic stem cell homeostasis maintenance and fate determination.Stem cell research & therapy · 2026Review
- Mitochondrial Regulation of Periodontal Ligament Stem Cell Fate and Function.Stem cell reviews and reports · 2026Review
- Metabolic and epigenetic interplay in HSPC specification: A balance between extrinsic and intrinsic cues.iScience · 2026Review
- Intrinsic and niche-dependent metabolic regulation of haematopoietic stem cells and implications for leukaemogenesis.Nature cell biology · 2026Review
- Glycolysis and glycolytic enzymes in acute myeloid leukemia: Warburg and beyond.Frontiers in pharmacology · 2026Review
- Dysregulation of HOXA genes in acute myeloid leukemia and targeted therapy.NPJ precision oncology · 2025Review
- Fumarate Restrains Alveolar Bone Restoration via Regulating H3K9 Methylation.Journal of dental research · 2024Article
- Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood.Stem cell research & therapy · 2024Article
- The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia.Nature cancer · 2024Article
- Article
- Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming.Life science alliance · 2024Article
- Genomics-based analysis of four porcine-derived lactic acid bacteria strains and their evaluation as potential probiotics.Molecular genetics and genomics : MGG · 2024Article
- Metabolic regulation of the hallmarks of stem cell biology.Cell stem cell · 2024Review
- Haematopoietic development and HSC formation in vitro: promise and limitations of gastruloid models.Emerging topics in life sciences · 2023Review
- Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia.The EMBO journal · 2023Review
- Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism.British journal of cancer · 2023Review
- The Interplay between Dysregulated Metabolism and Epigenetics in Cancer.Biomolecules · 2023Review
- Metabolic control of induced pluripotency.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
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Authors and funding
30 authors at 8 institutions in 2 countries.
Amelie V GuitartMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0002-2336-7716
Theano I PanagopoulouMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0003-2947-216X
Arnaud VillacrecesMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0002-2868-2264
Milica VukovicMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Catarina SepulvedaMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0002-1307-8101
Lewis AllenMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0003-4975-9563
Roderick N CarterCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0001-6565-9939
Louie N van de LagemaatMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Marcos MorganMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Peter GilesWales Gene Park and Wales Cancer Research Centre, Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF10 3XQ, Wales, UK.ORCID 0000-0003-3143-6854
Zuzanna SasMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0001-7815-7938
Marta Vila GonzalezMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Hannah LawsonMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0003-1450-1343
Jasmin ParisMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Joy Edwards-HicksEdinburgh Cancer Research UK Centre, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0001-7557-3960
Katrin SchaakMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0001-6395-4184
Chithra SubramaniMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0002-0735-0172
Deniz GezerMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Alejandro Armesilla-DiazMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0002-3874-4115
Jimi WillsEdinburgh Cancer Research UK Centre, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Aaron EasterbrookMater Children's Private Hospital Brisbane, South Brisbane, Queensland 4101, Australia.ORCID 0000-0002-6883-6846
David ComanDepartment of Metabolic Medicine, The Lady Cilento Children's Hospital, South Brisbane, Queensland 4101, Australia.
Chi Wai Eric SoDepartment of Haematological Medicine, Division of Cancer Studies, King's College London, London WC2R 2LS, England, UK.
Donal O'CarrollMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Douglas VernimmenThe Roslin Institute, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Neil P RodriguesThe European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff CF10 3XQ, Wales, UK.
Patrick J PollardEdinburgh Cancer Research UK Centre, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Nicholas M MortonCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.
Andrew FinchEdinburgh Cancer Research UK Centre, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.ORCID 0000-0002-8065-4623
Kamil R KrancMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK kamil.kranc@ed.ac.uk.ORCID 0000-0001-7547-4989
MRC Centre for Regenerative Medicine · GBEdinburgh Cancer Research · GBCardiff University · GBRoslin Institute · GBThe Queen's Medical Research Institute · GBChildren's Health Queensland Hospital and Health Service · AUKing's College London · GBMater Private Hospital · AU
Funding
Cancer Research UK 14633Cancer Research UK 16753Medical Research Council MR/K017047/1Medical Research Council MR/L012766/1Medical Research Council MR/P010008/1Wellcome Trust
Abstract
Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic hematopoiesis. Hematopoiesis-specific
Indexed as
AnimalsFemaleFumarate HydrataseFumaratesHematopoiesisHematopoietic Stem CellsHistonesLeukemia, Myeloid, AcuteMiceMice, Inbred C57BLMitochondriaNF-E2-Related Factor 2Oxygen ConsumptionFumarate HydrataseFumaratesHistonesNfe2l2 protein, mouseNF-E2-Related Factor 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.