ArticleJournal of the American Heart Association2017
Thrombus Migration in the Middle Cerebral Artery: Incidence, Imaging Signs, and Impact on Success of Endovascular Thrombectomy.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Effects of thrombus migration on endovascular treatment outcomes in patients with ischemic stroke: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- Direct aspiration versus stent retriever as First-line thrombectomy techniques for acute Basilar artery occlusions: an updated systematic review and Meta-Analysis.Neuroradiology · 2025Pooled it
- Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy.Stroke and vascular neurology · 2024Trial
- Trial
- Endovascular Treatment With or Without Prior Intravenous Alteplase for Acute Ischemic Stroke.Journal of the American Heart Association · 2019Trial
- Endovascular Treatment: The Role of Dominant Caliber M2 Segment Occlusion in Ischemic Stroke.Stroke · 2019Trial
- Thrombus Migration After Tenecteplase Versus Alteplase in Acute Large Vessel Occlusion.Journal of stroke · 2026Article
- Is early thrombectomy of proximal middle cerebral artery occlusion to salvage internal capsule associated with improved clinical outcomes?Frontiers in stroke · 2026Article
- Engineered nanoconjugates for simultaneous detection and degradation of stroke-associated microthrombi.Theranostics · 2026Article
- Is There a Relationship Between the Histopathological Features and Anatomical Locations of Thrombi Obtained During Endovascular Thrombectomy in Acute Ischemic Stroke and Its Comorbid Diseases?Diagnostics (Basel, Switzerland) · 2025Article
- Thrombus iodine-based perviousness is associated with recanalisation and functional outcomes in endovascular thrombectomy.Stroke and vascular neurology · 2025Article
- Self-Sensing with Hollow Cylindrical Transducers for Histotripsy-Enhanced Aspiration Mechanical Thrombectomy Applications.Sensors (Basel, Switzerland) · 2025Article
- Effectiveness of intravenous thrombolysis in patients with large-vessel occlusion receiving endovascular treatment in Korea.Acute and critical care · 2025Article
- Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion.Wiener klinische Wochenschrift · 2025Article
- Clot migration in patients treated with tenecteplase versus alteplase before mechanical thrombectomy.European stroke journal · 2025Article
- Cross-Sectional Imaging Modalities in Correlation to the Thrombolysis in Cerebral Infarction Score: The Next Frontier in Adjunctive Endovascular Stroke Therapy.Stroke (Hoboken, N.J.) · 2025Review
- Thrombus migration in intracranial large vessel occlusion: course, predictors, and impact on endovascular thrombectomy.Frontiers in neurology · 2025Article
- Endovascular treatment for secondary basilar occlusion caused by spontaneous thrombus migration from the vertebral artery: Two case reports.Radiology case reports · 2024Article
- Article
- Effect of Bridging Thrombolysis on the Efficacy of Stent Retriever Thrombectomy Techniques : Insights from the SWIFT-DIRECT trial.Clinical neuroradiology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThrombus migration (TM) in intracranial vessels during ischemic stroke has been reported in the form of case reports, but its incidence, impact on the technical success of subsequent endovascular thrombectomy and patients' outcome have never been studied systematically. METHODS AND
resultsRetrospective analysis was done of 409 patients with isolated middle cerebral artery occlusions treated with endovascular thrombectomy. TM was observed (1) by analyzing discrepancies between computed tomographic angiography and digital subtraction angiography and (2) by comparing infarct pattern in the striatocapsular region with exact, angiographically assessed thrombus location within the M1-segment and the involvement of the middle cerebral artery perforators. Preinterventional infarction of discrepant regions (infarction in regions supplied by more proximal vessels than those occluded by the clot) was ensured by carefully reviewing available preinterventional multimodal imaging. Adequate imaging inclusion criteria were met by 325 patients. Ninety-seven patients showed signs of TM (26 with direct evidence, 71 with indirect evidence). There was no difference in the frequency of preinterventional intravenous recombinant tissue plasminogen activator administration between patients with TM and those without (63.9% vs 64.9%,
conclusionsPreinterventional TM does not seem to be facilitated by intravenous recombinant tissue plasminogen activator and often occurs spontaneously. However, TM is associated with the risk of incomplete reperfusion in subsequent thrombectomy, suggesting increased clot fragility. Occurrence of TM may thereby have a substantial impact on the outcome of endovascularly treated stroke patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.