Evidence map›Paper›PMID 28202351›Full record

ArticleCancer letters2017

Exosomal formulation of anthocyanidins against multiple cancer types.

Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish K Agrawal, Ashley M Mudd, Al Hassan Kyakulaga, Inder P Singh, Manicka V Vadhanam, Ramesh C Gupta

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 220 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Therapeutic Potential of Bovine Milk-Derived Extracellular Vesicles.International journal of molecular sciences · 2024
    Review

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Radha MunagalaJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Farrukh AqilJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Jeyaprakash JeyabalanJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Ashish K AgrawalJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Ashley M MuddDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Al Hassan KyakulagaDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Inder P SinghNational Institute of Pharmaceutical Education and Research, S.A.S Nagar, India.
Manicka V VadhanamJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Ramesh C GuptaJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA. Electronic address: rcgupta@louisville.edu.
University of Louisville · USNational Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad · IN

Funding

UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1M
NIEHS NIH HHS T32 ES011564
6 · The paper itself

Abstract

Over the last two decades, berries and berry bioactives, particularly anthocyanins and their aglycones anthocyanidins (Anthos) have demonstrated excellent anti-oxidant, anti-proliferative, apoptotic and anti-inflammatory properties. However, their physicochemical and pharmacokinetic limitations such as, low permeability, and poor oral bioavailability are considered as unfavorable properties for development as drugs. Therefore there is a need to develop systems for efficient systemic delivery and robust bioavailability. In this study we prepared nano-formulation of bilberry-derived Anthos using exosomes harvested from raw bovine milk. Exosomal formulation of Anthos enhanced antiproliferative and anti-inflammatory effects compared with the free Anthos against various cancer cells in vitro. Our data also showed significantly enhanced therapeutic response of exosomal-Anthos formulation compared with the free Anthos against lung cancer tumor xenograft in nude mice. The Anthos showed no signs of gross or systemic toxicity in wild-type mice. Thus, exosomes provide an effective alternative for oral delivery of Anthos that is efficacious, cost-effective, and safe, and this regimen can be developed as a non-toxic, widely applicable therapeutic agent.

Indexed as

Drug CarriersA549 CellsAdministration, OralAnimalsAnthocyaninsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicCell ProliferationDose-Response Relationship, DrugDrug CompoundingExosomesFemaleHCT116 CellsHumansMaleMCF-7 CellsAnthocyaninsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicDrug CarriersAnthocyanidinsAnti-cancerAnti-inflammatoryDrug deliveryMilk exosomes

Identifiers

PMID28202351
PMCPMC5837866
OpenAlexW2588236705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.