ArticleCortex; a journal devoted to the study of the nervous system and behavior2017
Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis.Dialogues in clinical neuroscience · 2026Pooled it
- Emerging behavioral and neuroimaging biomarkers for early and accurate characterization of autism spectrum disorders: a systematic review.Translational psychiatry · 2021Pooled it
- Myelin, white matter, and social deficits in autism spectrum disorder.Neural regeneration research · 2026Article
- Perinatal brain growth and autistic traits in toddlers.Translational psychiatry · 2025Article
- White matter microstructure as a potential contributor to differences in resting state alpha activity between neurotypical and autistic children: a longitudinal multimodal imaging study.Molecular autism · 2025Article
- The correlation between brain structure characteristics and emotion regulation ability in children at high risk of autism spectrum disorder.European child & adolescent psychiatry · 2024Article
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Pathways to Psychopathology Among Autistic Adults.Current psychiatry reports · 2023Review
- Differential impacts ofFrontiers in neuroscience · 2023Article
- Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Sex differences in microstructural alterations in the corpus callosum tracts in drug-naïve children with ADHD.Brain imaging and behavior · 2022Article
- Neuronal and glial cell number is altered in a cortical layer-specific manner in autism.Autism : the international journal of research and practice · 2021Article
- A Longitudinal Study of White Matter Development in Relation to Changes in Autism Severity Across Early Childhood.Biological psychiatry · 2021Article
- Neuroimaging Markers of Risk and Pathways to Resilience in Autism Spectrum Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Functional and Neuropathological Evidence for a Role of the Brainstem in Autism.Frontiers in integrative neuroscience · 2021Article
- The Neurodevelopment of Autism from Infancy Through Toddlerhood.Neuroimaging clinics of North America · 2020Review
- A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children.Journal of neurodevelopmental disorders · 2019Article
- Precocious myelination in a mouse model of autism.Translational psychiatry · 2019Article
- Age-Dependent White Matter Characteristics of the Cerebellar Peduncles from Infancy Through Adolescence.Cerebellum (London, England) · 2019Article
- The Protracted Maturation of Associative Layer IIIC Pyramidal Neurons in the Human Prefrontal Cortex During Childhood: A Major Role in Cognitive Development and Selective Alteration in Autism.Frontiers in psychiatry · 2019Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Interhemispheric functional connectivity abnormalities are often reported in autism and it is thus not surprising that structural defects of the corpus callosum (CC) are consistently found using both traditional MRI and DTI techniques. Past DTI studies however, have subdivided the CC into 2 or 3 segments without regard for where fibers may project to within the cortex, thus placing limitations on our ability to understand the nature, timing and neurobehavioral impact of early CC abnormalities in autism. Leveraging a unique cohort of 97 toddlers (68 autism; 29 typical) we utilized a novel technique that identified seven CC tracts according to their cortical projections. Results revealed that younger (<2.5 years old), but not older toddlers with autism exhibited abnormally low mean, radial, and axial diffusivity values in the CC tracts connecting the occipital lobes and the temporal lobes. Fractional anisotropy and the cross sectional area of the temporal CC tract were significantly larger in young toddlers with autism. These findings indicate that water diffusion is more restricted and unidirectional in the temporal CC tract of young toddlers who develop autism. Such results may be explained by a potential overabundance of small caliber axons generated by excessive prenatal neural proliferation as proposed by previous genetic, animal model, and postmortem studies of autism. Furthermore, early diffusion measures in the temporal CC tract of the young toddlers were correlated with outcome measures of autism severity at later ages. These findings regarding the potential nature, timing, and location of early CC abnormalities in autism add to accumulating evidence, which suggests that altered inter-hemispheric connectivity, particularly across the temporal lobes, is a hallmark of the disorder.
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