SynthesisPsychological medicine2017
Gene-environment interplay in depressive symptoms: moderation by age, sex, and physical illness.
Synthesis in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Trial
- The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2026Article
- Dementia risk by metabolic health and obesity in two prospective cohorts.BMC medicine · 2026Article
- The role of common mental disorders on sustainable working life-a cohort study among discordant Swedish twin pairs.BMJ open · 2025Article
- Terminal Increases in Depressive Symptoms in a Multinational Twin Consortium.Psychological science · 2025Article
- Develop and validate machine learning models to predict the risk of depressive symptoms in older adults with cognitive impairment.BMC psychiatry · 2025Article
- Longitudinal relationships between depressive symptoms, functional impairment, and physical activity in later late life.GeroScience · 2025Article
- Age and Sex Differences in the Genetic Architecture of Measures of Subjective Health: Relationships With Physical Health, Depressive Symptoms, and Episodic Memory.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- Air Pollution and the Dynamic Association Between Depressive Symptoms and Memory in Oldest-Old Women.Journal of the American Geriatrics Society · 2021Article
- Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.Frontiers in psychiatry · 2020Review
- Particulate Air Pollutants and Trajectories of Depressive Symptoms in Older Women.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Article
- RDoC and Psychopathology among Youth: Misplaced Assumptions and an Agenda for Future Research.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 5 countries.
Funding
Abstract
backgroundNumerous factors influence late-life depressive symptoms in adults, many not thoroughly characterized. We addressed whether genetic and environmental influences on depressive symptoms differed by age, sex, and physical illness.
methodThe analysis sample included 24 436 twins aged 40-90 years drawn from the Interplay of Genes and Environment across Multiple Studies (IGEMS) Consortium. Biometric analyses tested age, sex, and physical illness moderation of genetic and environmental variance in depressive symptoms.
resultsWomen reported greater depressive symptoms than men. After age 60, there was an accelerating increase in depressive symptom scores with age, but this did not appreciably affect genetic and environmental variances. Overlap in genetic influences between physical illness and depressive symptoms was greater in men than in women. Additionally, in men extent of overlap was greater with worse physical illness (the genetic correlation ranged from near 0.00 for the least physical illness to nearly 0.60 with physical illness 2 s.d. above the mean). For men and women, the same environmental factors that influenced depressive symptoms also influenced physical illness.
conclusionsFindings suggested that genetic factors play a larger part in the association between depressive symptoms and physical illness for men than for women. For both sexes, across all ages, physical illness may similarly trigger social and health limitations that contribute to depressive symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.