ArticleParasites & vectors2017
Tick-borne pathogens induce differential expression of genes promoting cell survival and host resistance in Ixodes ricinus cells.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
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- Haemaphysalis longicornis HSP20 inhibits Rickettsia heilongjiangensis replication by targeting the pathogen 50S ribosomal protein.Parasites & vectors · 2026Article
- Insights into tick-pathogen interactions - a single cell RNA sequencing approach of transcriptional changes during ehrlichial infection.bioRxiv : the preprint server for biology · 2026Article
- When Metabolomics Meets Quantitative Genetics: An Integrative Strategy to Elucidate Plant Resistance Mechanisms.Plant, cell & environment · 2026Review
- Characterization of two novel defensins Han-Def1 and Han-Def2 fromFrontiers in microbiology · 2026Article
- Comparative analysis of defensin expression inFrontiers in veterinary science · 2026Article
- Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells.PLoS pathogens · 2025Article
- Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors.Nature communications · 2025Article
- Potential mechanisms implied in tick infection by arboviruses and their transmission to vertebrate hosts.Integrative zoology · 2025Review
- Investigation of genes expression of the JAK/STAT signalling pathway and AMPs in the presence of Borrelia spirochetes in Ixodes ricinus.Scientific reports · 2025Article
- Integrated transcriptomic and proteomic analysis of the immune response inFrontiers in immunology · 2025Article
- Vectorial dynamics underpinning current and future tick-borne virus emergence in Europe.The Journal of general virology · 2024Review
- Comparative Analysis of Bisexual and Parthenogenetic Populations in Haemaphysalis Longicornis.Microorganisms · 2024Article
- Towards modelling tick-virus interactions using the weakly pathogenicFrontiers in cellular and infection microbiology · 2024Article
- Prevalence and genetic diversity ofFrontiers in veterinary science · 2024Article
- Metagenomics Characterization ofJournal of arthropod-borne diseases · 2023Article
- Integrative analysis highlights molecular and immune responses of tickFrontiers in cellular and infection microbiology · 2023Article
- Article
- What do we know about the microbiome ofFrontiers in cellular and infection microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThere has been an emergence and expansion of tick-borne diseases in Europe, Asia and North America in recent years, including Lyme disease, tick-borne encephalitis and human anaplasmosis. The primary vectors implicated are hard ticks of the genus Ixodes. Although much is known about the host response to these bacterial and viral pathogens, there is limited knowledge of the cellular responses to infection within the tick vector. The bacterium Anaplasma phagocytophilum is able to bypass apoptotic processes in ticks, enabling infection to proceed. However, the tick cellular responses to infection with the flaviviruses tick-borne encephalitis virus (TBEV) and louping ill virus (LIV), which cause tick-borne encephalitis and louping ill respectively, are less clear.
resultsInfection and transcriptional analysis of the Ixodes ricinus tick cell line IRE/CTVM20 with the viruses LIV and TBEV, and the bacterium A. phagocytophilum, identified activation of common and distinct cellular pathways. In particular, commonly-upregulated genes included those that modulate apoptotic pathways, putative anti-pathogen genes, and genes that influence the tick innate immune response, including selective activation of toll genes.
conclusionThese data provide an insight into potential key genes involved in the tick cellular response to viral or bacterial infection, which may promote cell survival and host resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.