SynthesisMalaria journal2017
Alternative transmission routes in the malaria elimination era: an overview of transfusion-transmitted malaria in the Americas.
Synthesis in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Evaluation of the malaria elimination policy in Brazil: a systematic review and epidemiological analysis study.Tropical biomedicine · 2020Pooled it
- A systematic review of transfusion-transmitted malaria in non-endemic areas.Malaria journal · 2018Pooled it
- The Landscape of Malaria in a Five-Decade Institution in the State of Amazonas: Historical Trends, Scientific Contributions, and Research Priorities.Revista da Sociedade Brasileira de Medicina Tropical · 2026Review
- Molecular test for screening malaria-infected blood donors to maximise recipient safety in Acre State, a Brazilian endemic area.Memorias do Instituto Oswaldo Cruz · 2024Article
- Reaching the malaria elimination goal in Brazil: a spatial analysis and time-series study.Infectious diseases of poverty · 2022Article
- Article
- Transfusion-Transmitted Malaria: Two Pediatric Cases From the United States and Their Relevance in an Increasingly Globalized World.Journal of the Pediatric Infectious Diseases Society · 2021Article
- Current Situation of Transfusion-Transmitted Malaria in China.Journal of tropical medicine · 2021Review
- Use of a NAT-based assay to improve the surveillance system and prevent transfusion-transmitted malaria in blood banks.Malaria journal · 2020Article
- Inactivation of Plasmodium falciparum in whole blood using the amustaline and glutathione pathogen reduction technology.Transfusion · 2020Article
- Malaria Resurgence in the Americas: An Underestimated Threat.Pathogens (Basel, Switzerland) · 2019Article
- Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination.Malaria journal · 2017Review
- Improving blood safety: NAT-based detection of Plasmodium spp. in blood donors in endemic areas of Brazil.Blood transfusion = Trasfusione del sangueObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransfusion-transmitted (TT) malaria is an alternative infection route that has gained little attention from authorities, despite representing a life-threatening condition. There has been no systematic review of this health problem in American countries. The aim of this study was to describe the clinical and epidemiological characteristics of TT malaria in the Americas and identify factors associated with lethality based on the studies published in the literature.
methodsPotentially relevant papers in all languages were retrieved from MEDLINE and LILACS. Additional articles were obtained from reviews and original papers. Publications on screening of candidate blood donors and on surveillance of TT malaria cases were included. Odds ratios with respective 95% confidence intervals (95% CI) were calculated. Epidemiological characteristics of blood donors of TT malaria cases, including a pooled positivity of different tests for malaria diagnosis, were retrieved.
resultsA total of 63 publications regarding TT malaria from seven countries were included, from 1971 to 2016. A total of 422 cases of TT malaria were recorded. Most TT malaria cases were in females (62.0%) and 39.5% were in the ≥61 years-old age group. About half of all cases were from Mexico (50.7%), 40.3% from the United States of America (USA) and 6.6% from Brazil. Gyneco-obstetrical conditions (67.3%), surgical procedures (20.6%) and complications from neoplasias (6.1%) were the most common indications of transfusion. Packed red blood cells (RBCs) (50.7%) and whole blood (43.3%) were the blood products mostly associated with TT malaria. Cases were mostly caused by Plasmodium malariae (58.4%), followed by Plasmodium vivax (20.7%) and Plasmodium falciparum (17.9%). A total of 66.6% of cases were diagnosed by microscopy. Incubation period of 2-3 weeks was the most commonly observed (28.6%). Lethality was seen in 5.3% of cases and was associated with living in non-endemic countries, P. falciparum infection and concomitant neoplastic diseases.
conclusionThere is an important research and knowledge gap regarding the TT malaria burden in Latin American countries where malaria remains endemic. No screening method that is practical, affordable and suitably sensitive is available at blood banks in Latin American countries, where infections with low parasitaemia contribute greatly to transmission. Lethality from TT malaria was not negligible. TT malaria needs to be acknowledged and addressed in areas moving toward elimination.
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