Evidence map›Paper›PMID 28201999›Full record

ArticleBMC cancer2017

Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer.

Ivonne Lozano-Pope, Arnika Sharma, Michael Matthias, Kelly S Doran, Marygorret Obonyo

Open access · goldAbstract read
In one paragraph

Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. TRIF-IFN-I pathway iniScience · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Molecular biology of BPIFB1 and its advances in disease.Annals of translational medicine · 2020
    Review
  12. Article
  13. Joint analysis of lncRNA mCancer cell international · 2020
    Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ivonne Lozano-PopeDepartment of Medicine, University of California, La Jolla, CA, USA.
Arnika SharmaDepartment of Biology, San Diego State University, San Diego, CA, USA.
Michael MatthiasDepartment of Medicine, University of California, La Jolla, CA, USA.
Kelly S DoranDepartment of Biology, San Diego State University, San Diego, CA, USA.
Marygorret ObonyoDepartment of Medicine, University of California, La Jolla, CA, USA. mobonyo@ucsd.edu.ORCID 0000-0001-8703-8404
University of California San Diego · USSan Diego State University · US

Funding

Research Education CoreU54CA132384 · NCI · SAN DIEGO STATE UNIVERSITY · PI CRIPPS, RICHARD MATTHEW, CROWE, SHEILA E. · 2008 to 2022
$20.7M
Research Education CoreU54CA132379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARREDONDO, ELVA M, CROWE, SHEILA E. · 2008 to 2021
$16.1M
B12 Autotrophy as a Virulence Mechanism in Infectious LeptospiraR21AI115273 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MATTHIAS, MICHAEL A · 2015 to 2016
$426k
Role of inflammatory microenvironment in Helicobacter-induced gastric cancerR21CA188752 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OBONYO, MARYGORRET · 2015 to 2016
$371k
NCI NIH HHS R21 CA188752NCI NIH HHS U54 CA132379NCI NIH HHS U54 CA132384NIAID NIH HHS R21 AI115273
6 · The paper itself

Abstract

backgroundGastric cancer is one of the most common and lethal type of cancer worldwide. Infection with Helicobacter pylori (H. pylori) is recognized as the major cause of gastric cancer. However, it remains unclear the mechanism by which Helicobacter infection leads to gastric cancer. Furthermore, the underlying molecular events involved during the progression of Helicobacter infection to gastric malignancy are not well understood. In previous studies, we demonstrated that that H. felis-infected Myd88

methodsWild type (WT) and Myd88 deficient mice (Myd88

resultsHelicobacter infection affected the transcriptional profile of more genes in Myd88

conclusionsThese results provide a global transcriptional gene profile during the development and progression of Helicobacter-induced gastric cancer. The data show that our mouse model system is useful for identifying genes involved in gastric cancer progression.

Indexed as

Gene Expression ProfilingGene Regulatory NetworksAnimalsBiomarkers, TumorDisease Models, AnimalDisease ProgressionHelicobacter InfectionsHelicobacter pyloriMiceMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88Stomach NeoplasmsBiomarkers, TumorMyd88 protein, mouseMyeloid Differentiation Factor 88Gastric cancerGene regulationHelicobacterMicroarrayMyD88

Identifiers

PMID28201999
PMCPMC5310019
OpenAlexW2588199737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.