ArticleBMC genetics2017
Molecular characterization of MHC class IIB genes of sympatric Neotropical cichlids.
Article in BMC genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Evolutionary dynamics of pre- and postzygotic reproductive isolation in cichlid fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Pooled it
- Macroimmunology: The drivers and consequences of spatial patterns in wildlife immune defence.The Journal of animal ecology · 2020Pooled it
- Unheralded high MHC class II polymorphism in the abundant Atlantic herring resolved by long-read sequencing.Science advances · 2026Article
- Association of MHC class II β domain polymorphism in channel catfish (Ictalurus punctatus) with natural infection by Ligictaluridus floridanus.Parasitology research · 2025Article
- Evolution of MHC IIB Diversity Across Cichlid Fish Radiations.Genome biology and evolution · 2023Review
- Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula).Scientific reports · 2023Article
- Divergent and non-parallel evolution of MHC IIB in the Neotropical Midas cichlid species complex.BMC ecology and evolution · 2022Article
- Trans-specific polymorphism and the convergent evolution of supertypes in major histocompatibility complex class II genes in darters (Ecology and evolution · 2022Article
- Molecular and Structural Characterization of MHC Class II β Genes Reveals High Diversity in the Cold-Adapted Icefish Chionodraco hamatus.Scientific reports · 2019Article
- An exploration of the links between parasites, trophic ecology, morphology, and immunogenetics in the Lake Tanganyika cichlid radiation.Hydrobiologia · 2019Article
- Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus.Environmental science and pollution research international · 2018Article
- Immune-Related Transcriptional Responses to Parasitic Infection in a Naturally Inbred Fish: Roles of Genotype and Individual Variation.Genome biology and evolution · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Major Histocompatibility Complex (MHC) is a key component of the adaptive immune system of all vertebrates and consists of the most polymorphic genes known to date. Due to this complexity, however, MHC remains to be characterized in many species including any Neotropical cichlid fish. Neotropical crater lake cichlids are ideal models to study evolutionary processes as they display one of the most convincing examples of sympatric and repeated parallel radiation events within and among isolated crater lakes.
resultsHere, we characterized the genes of MHC class IIB chain of the Midas cichlid species complex (Amphilophus cf. citrinellus) including fish from five lakes in Nicaragua. We designed 19 new specific primers anchored in a stepwise fashion in order to detect all alleles present. We obtained 866 genomic DNA (gDNA) sequences from thirteen individuals and 756 additional sequences from complementary DNA (cDNA) of seven of those individuals. We identified 69 distinct alleles with up to 25 alleles per individual. We also found considerable intron length variation and mismatches of alleles detected in cDNA and gDNA suggesting that some loci have undergone pseudogenization. Lastly, we created a model of protein structure homology for each allele and identified their key structural components.
conclusionsOverall, the Midas cichlid has one of the most diverse repertoires of MHC class IIB genes known, which could serve as a powerful tool to elucidate the process of divergent radiations, colonization and speciation in sympatry.
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