ArticleBMC genomics2017
An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- A systematic review of skin ageing genes: gene pleiotropy and genes on the chromosomal band 16q24.3 may drive skin ageing.Scientific reports · 2022Pooled it
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- Ex Vivo and In Vivo Histological Evaluation of a 3-μm Wavelength, 40-μm Spot Size Fractional Laser System for Dermatology.Lasers in surgery and medicine · 2026Article
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Nicotinamide Improves Skin Photoaging in Mice by Delaying Cellular Senescence and Suppressing the Senescence-Associated Secretory Phenotype.Current issues in molecular biology · 2026Article
- Article
- Investigating the Dynamic Variation of Skin Microbiota and Metabolites in Bats During Hibernation.Biology · 2025Article
- Proteomics-based mechanism of HIIT regulation of hepatic metabolism in aging female rats.Biogerontology · 2025Article
- Digestive Stability and Enzyme Inhibitory Potential ofIranian journal of public health · 2025Article
- Chamazulene Induces Metabolic Reprogramming and Mitigates Inflammation in Photoaged Skin: PPARα/γ as Potential Regulators.Antioxidants (Basel, Switzerland) · 2025Article
- Article
- Alternatives Integrating Omics Approaches for the Advancement of Human Skin Models: A Focus on Metagenomics, Metatranscriptomics, and Metaproteomics.Microorganisms · 2025Review
- SenSkin™: a human skin-specific cellular senescence gene set.GeroScience · 2025Article
- Study on the Effect of Bee Venom and Its Main Component Melittin in Delaying Skin Aging in Mice.International journal of molecular sciences · 2025Article
- Selenomethionine in gelatin methacryloyl hydrogels: Modulating ferroptosis to attenuate skin aging.Bioactive materials · 2024Article
- Integrative Multiomics Approach to Skin: The Sinergy between Individualised Medicine and Futuristic Precision Skin Care?Metabolites · 2024Review
- Proline restores mitochondrial function and reverses aging hallmarks in senescent cells.Cell reports · 2024Article
- CAT Bridge: an efficient toolkit for gene-metabolite association mining from multiomics data.GigaScience · 2024Article
- The quest to define senescence.Frontiers in genetics · 2024Article
- Network Pharmacology with Metabolomics Study to Reveal the Mechanisms of Bushen Huoxue Formula in Intervertebral Disc Degeneration Treatment.Drug design, development and therapy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging human skin undergoes significant morphological and functional changes such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier function. Besides known age-related alterations like DNA-methylation changes, metabolic adaptations have been recently linked to impaired skin function in elder humans. Understanding of these metabolic adaptations in aged skin is of special interest to devise topical treatments that potentially reverse or alleviate age-dependent skin deterioration and the occurrence of skin disorders.
resultsWe investigated the global metabolic adaptions in human skin during aging with a combined transcriptomic and metabolomic approach applied to epidermal tissue samples of young and old human volunteers. Our analysis confirmed known age-dependent metabolic alterations, e.g. reduction of coenzyme Q10 levels, and also revealed novel age effects that are seemingly important for skin maintenance. Integration of donor-matched transcriptome and metabolome data highlighted transcriptionally-driven alterations of metabolism during aging such as altered activity in upper glycolysis and glycerolipid biosynthesis or decreased protein and polyamine biosynthesis. Together, we identified several age-dependent metabolic alterations that might affect cellular signaling, epidermal barrier function, and skin structure and morphology.
conclusionsOur study provides a global resource on the metabolic adaptations and its transcriptional regulation during aging of human skin. Thus, it represents a first step towards an understanding of the impact of metabolism on impaired skin function in aged humans and therefore will potentially lead to improved treatments of age related skin disorders.
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