ArticleAmerican journal of hypertension2017
Associations Between Genetic Variants of NADPH Oxidase-Related Genes and Blood Pressure Responses to Dietary Sodium Intervention: The GenSalt Study.
Article in American journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Salt and chronic kidney disease.Nature reviews. Nephrology · 2026Review
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- Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications.Antioxidants (Basel, Switzerland) · 2025Review
- Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt).Chronic diseases and translational medicine · 2021Article
- The Counteracting Effects of Demography on Functional Genomic Variation: The Roma Paradigm.Molecular biology and evolution · 2021Article
- Oxidative Stress and Hypertension.Circulation research · 2021Review
- Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Role of Rho in Salt-Sensitive Hypertension.International journal of molecular sciences · 2021Review
- Sodium sensitivity of blood pressure in Chinese populations.Journal of human hypertension · 2020Review
- Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation.The pharmacogenomics journal · 2019Review
- NOX5: Molecular biology and pathophysiology.Experimental physiology · 2019Review
- Association of Kir genes with blood pressure responses to dietary sodium intervention: the GenSalt study.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Associations of NADPH oxidase-related genes with blood pressure changes and incident hypertension: The GenSalt Study.Journal of human hypertension · 2018Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe aim of this study was to comprehensively test the associations of genetic variants of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-related genes with blood pressure (BP) responses to dietary sodium intervention in a Chinese population.
methodsWe conducted a 7-day low-sodium intervention followed by a 7-day high-sodium intervention among 1,906 participants in rural China. BP measurements were obtained at baseline and each dietary intervention using a random-zero sphygmomanometer. Linear mixed-effect models were used to assess the additive associations of 63 tag single-nucleotide polymorphisms in 11 NADPH oxidase-related genes with BP responses to dietary sodium intervention. Gene-based analyses were conducted using the truncated product method. The Bonferroni method was used to adjust for multiple testing in all analyses.
resultsSystolic BP (SBP) response to high-sodium intervention significantly decreased with the number of minor T allele of marker rs6967221 in RAC1 (P = 4.51 × 10-4). SBP responses (95% confidence interval) for genotypes CC, CT, and TT were 5.03 (4.71, 5.36), 4.20 (3.54, 4.85), and 0.56 (-1.08, 2.20) mm Hg, respectively, during the high-sodium intervention. Gene-based analyses revealed that RAC1 was significantly associated with SBP response to high-sodium intervention (P = 1.00 × 10-6) and diastolic BP response to low-sodium intervention (P = 9.80 × 10-4).
conclusionsThese findings suggested that genetic variants of NADPH oxidase-related genes may contribute to the variation of BP responses to sodium intervention in Chinese population. Further replication of these findings is warranted.
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