Evidence map›Paper›PMID 28199837›Full record

ArticleCell reports2017

An Endosomal NAADP-Sensitive Two-Pore Ca

Bethan S Kilpatrick, Emily R Eden, Leanne N Hockey, Elizabeth Yates, Clare E Futter, Sandip Patel

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 2 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Allosteric switching of CaThe EMBO journal · 2026
    Article
  5. Review
  6. Organelle contact sites in cancer cells.Cell death & disease · 2026
    Review
  7. Review
  8. Review
  9. Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Inter-Organellar CaCells · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  18. Article
  19. Article
  20. Review

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bethan S KilpatrickDepartment of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
Emily R EdenDepartment of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
Leanne N HockeyDepartment of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
Elizabeth YatesDepartment of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
Clare E FutterDepartment of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK. Electronic address: c.futter@ucl.ac.uk.
Sandip PatelDepartment of Cell and Developmental Biology, University College London, London WC1E 6BT, UK. Electronic address: patel.s@ucl.ac.uk.
University College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G013721/1Medical Research Council G0801878Medical Research Council MR/M010767/1Parkinson's UK H-1202Parkinson's UK K-1107Parkinson's UK K-1412Wellcome Trust 093445
6 · The paper itself

Abstract

Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca

Indexed as

CalciumCalcium ChannelsCalcium SignalingCell Line, TumorCells, CulturedEndoplasmic ReticulumEndosomesHeLa CellsHumansIntercellular Signaling Peptides and ProteinsLysosomesMembranesNADPPhosphorylationCalciumCalcium ChannelsIntercellular Signaling Peptides and ProteinsNAADPNADPacidic Ca(2+) storesCa(2+)EGFendoplasmic reticulumendosomeslysosomesmembrane contact sitesNAADPTPC1TPC2

Identifiers

PMID28199837
PMCPMC5318655
OpenAlexW2588744007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.