Evidence map›Paper›PMID 28199780›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017

Cytomegalovirus-Responsive CD8

L E Higdon, J Trofe-Clark, S Liu, K B Margulies, M K Sahoo, E Blumberg, B A Pinsky, J S Maltzman

Open access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Cellular Immunity in Chronic Kidney Disease and Changes After Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  5. Article
  6. Article
  7. T-cell receptor sequencing reveals selected donor-reactive CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  8. Article
  9. Functional Consequences of Memory Inflation after Solid Organ Transplantation.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. NK cell and Th17 responses are differentially induced in murine cytomegalovirus infected renal allografts and vary according to recipient virus dose and strain.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

L E HigdonDepartment of Medicine/Nephrology, Stanford University, Palo Alto, CA.
J Trofe-ClarkDepartment of Pharmacy Services, Hospital of the University of Pennsylvania, Philadelphia, PA.
S LiuDepartment of Medicine/Nephrology, Stanford University, Palo Alto, CA.
K B MarguliesPerelman School of Medicine, University of Pennsylvania, Cardiovascular Institute, Philadelphia, PA.
M K SahooStanford University, School of Medicine, Department of Pathology, Stanford, CA.
E BlumbergPerelman School of Medicine, University of Pennsylvania, Infectious Diseases Division, Philadelphia, PA.
B A PinskyStanford University, School of Medicine, Department of Pathology, Stanford, CA.
J S MaltzmanDepartment of Medicine/Nephrology, Stanford University, Palo Alto, CA.
Stanford University · USUniversity of Pennsylvania · USCardiovascular Institute of the South · USVA Palo Alto Health Care System · US

Funding

MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007357 · NIDDK · STANFORD UNIVERSITY · PI CHERTOW, GLENN MATTHEW · 1986 to 2022
$4.8M
NIAID NIH HHS T32 AI007290NIDDK NIH HHS T32 DK007357
6 · The paper itself

Abstract

Cytomegalovirus (CMV) is a major cause of morbidity and mortality in solid organ transplant recipients. Approximately 60% of adults are CMV seropositive, indicating previous exposure. Following resolution of the primary infection, CMV remains in a latent state. Reactivation is controlled by memory T cells in healthy individuals; transplant recipients have reduced memory T cell function due to chronic immunosuppressive therapies. In this study, CD8

Indexed as

Heart TransplantationKidney TransplantationCD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus InfectionsHumansImmunity, CellularLongitudinal Studiesbasic (laboratory) research/scienceflow cytometryimmune regulationimmunobiologyinfection and infectious agentsinfectious diseaseT cell biologyviral: Cytomegalovirus (CMV)

Identifiers

PMID28199780
PMCPMC5519416
OpenAlexW2589037683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.