Evidence map›Paper›PMID 28199764›Full record

Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2017

Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring.

R J Bertelsen, M Rava, A E Carsin, S Accordini, B Benediktsdóttir, J Dratva, K A Franklin, J Heinrich, M Holm, C Janson and 12 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017
    Trial
  2. Article
  3. The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Review
  4. Article
  5. The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?International journal of environmental research and public health · 2021
    Review
  6. [Levels of airway inflammatory mediators in peripheral blood in infants and young children with wheezing].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 13 countries.

R J BertelsenDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0001-5319-525X
M RavaINSERM U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France.
A E CarsinISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
S AccordiniUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
B BenediktsdóttirMedical Faculty, University of Iceland, Reykjavík, Iceland.
J DratvaDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
K A FranklinDepartment of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
J HeinrichHelmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany.
M HolmDepartment of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
C JansonDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-5093-6980
A JohannessenCentre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
D L JarvisRespiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK.
R JogiTartu University Hospital, Lung Clinic, Tartu, Estonia.
B LeynaertInserm, UMR 1152, Pathophysiology and Epidemiology of Respiratory Diseases, Epidemiology Team, Paris, France.
D NorbackDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
E R OmenaasDepartment of Clinical Science, University of Bergen, Bergen, Norway.
C RaherisonINSERM U897 Bordeaux University, Bordeaux Cedex, France.
J L Sánchez-RamosDepartment of Nursing, University of Huelva, Huelva, Spain.
V SchlünssenDepartment of Public Health, Aarhus University, Aarhus, Denmark.
T SigsgaardDepartment of Public Health, Aarhus University, Aarhus, Denmark.
S C DharmageAllergy and Lung Health Unit, Melbourne School of Population Health, The University of Melbourne, Melbourne, Vic., Australia.
C SvanesDepartment of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.
Haukeland University Hospital · NOInserm · FRAarhus University · DKUppsala University · SEHelmholtz Zentrum München · DENational Institutes of Health · USSahlgrenska University Hospital · SESwiss Tropical and Public Health Institute · CHTartu University Hospital · EEThe University of Melbourne · AUUmeå University · SEUniversidad de Huelva · ESUniversitat Pompeu Fabra · ESUniversity of Iceland · ISUniversity of Verona · IT

Funding

Medical Research Council G0901214Wellcome Trust
6 · The paper itself

Abstract

backgroundMice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans.

objectiveWe aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness (BHR), and total and specific IgEs, measured before conception vs. after birth, with offspring asthma and hayfever.

methodsThe study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey (ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991 to 1993, and data on 9100 offspring born 1972-2012. Adjusted relative risk ratios (aRRR) for associations of parental clinical outcome with offspring allergic disease were estimated with multinomial logistic regressions.

resultsOffspring asthma with hayfever was more strongly associated with parental BHR and specific IgE measured before conception than after birth [BHR: aRRR = 2.96 (95% CI: 1.92, 4.57) and 1.40 (1.03, 1.91), respectively; specific IgEs: 3.08 (2.13, 4.45) and 1.83 (1.45, 2.31), respectively]. This was confirmed in a sensitivity analysis of a subgroup of offspring aged 11-22 years with information on parental disease activity both before and after birth. CONCLUSION & CLINICAL RELEVANCE: Parental BHR and specific IgE were associated with offspring asthma and hayfever, with the strongest associations observed with clinical assessment before conception as compared to after birth of the child. If the hypothesis is confirmed in other studies, parental disease activity assessed before conception may prove useful for identifying children at risk for developing asthma with hayfever.

Indexed as

AdultAsthmaBiomarkersFemaleFollow-Up StudiesHumansImmunoglobulin EMaleRhinitis, Allergic, SeasonalBiomarkersImmunoglobulin Easthmaclinical immunologyepidemiologyEuropean Community Respiratory Health SurveyIgEoffspringpreconceptionrhinitis

Identifiers

PMID28199764
PMCPMC5447870
OpenAlexW2589059756

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.