ArticleSchizophrenia bulletin2017
The Effect of Substance Use on 10-Year Outcome in First-Episode Psychosis.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- COVID-19-associated psychosis: A systematic review of case reports.General hospital psychiatryPooled it
- Psychosocial Interventions, Recovery, and Mediating Mechanisms in Schizophrenia-Spectrum Disorders: A Systematic Review and Meta-Analysis of Longitudinal Studies.Brain sciences · 2026Review
- Global, regional and national burdens of schizophrenia in adolescents and young adults: a trend analysis and forecast from 1990 to 2021.European child & adolescent psychiatry · 2026Article
- Polygenic risk score for neurodevelopmental disorders and cognitive impairment at long-term follow-up of first-episode psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Developing a Substance Use Practice Approach for Peer Support Specialists in Early Psychosis Coordinated Specialty Care.Early intervention in psychiatry · 2026Article
- Development and validation of a model for predicting relapse in patients with first-episode schizophrenia.BMC psychiatry · 2026Article
- Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis.Biological psychiatry global open science · 2025Article
- Substance use approaches among peer support specialists in community mental health early psychosis programs.Psychiatric rehabilitation journal · 2025Article
- Communication Targets and Applications for Family Members of People With Early Psychosis and Substance Use.Early intervention in psychiatry · 2025Article
- Article
- Long-term clinical recovery and treatment resistance in first-episode psychosis: a 10-year follow-up study.Schizophrenia (Heidelberg, Germany) · 2024Article
- Tobacco, Alcohol, and Drug Use Among Young Adults with Serious Mental Illness.Community mental health journal · 2024Article
- Perspectives of young adults diagnosed with early psychosis using coordinated specialty care in Texas on substance use and substance use interventions.Early intervention in psychiatry · 2024Article
- Predictors of Readmission in Young Adults with First-Episode Psychosis: A Multicentric Retrospective Study with a 12-Month Follow-Up.Clinics and practice · 2024Article
- Contingency Management for Dually Diagnosed Inpatients with Psychosis.International journal of environmental research and public health · 2024Article
- The relationship between substance use and self-reported aspects of social functioning in patients with a psychotic disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Correlates of substance use in a large naturalistic cohort of young people with early and emerging psychosis.Social psychiatry and psychiatric epidemiology · 2023Article
- Early identification of treatment non-response in first-episode psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Barriers and Facilitators That Influence Providers' Ability to Educate, Monitor, and Treat Substance Use in First-Episode Psychosis Programs Using the Theoretical Domains Framework.Qualitative health research · 2021Article
- Development and Validation of a Nonremission Risk Prediction Model in First-Episode Psychosis: An Analysis of 2 Longitudinal Studies.Schizophrenia bulletin open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 10 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substance use is common in first-episode psychosis (FEP) and has been linked to poorer outcomes with more severe psychopathology and higher relapse rates. Early substance discontinuation appears to improve symptoms and function. However, studies vary widely in their methodology, and few have examined patients longitudinally, making it difficult to draw conclusions for practice and treatment. We aimed to investigate the relationship between substance use and early abstinence and the long-term course of illness in a representative sample of FEP patients. Out of 301 included patients, 266 could be divided into 4 groups based on substance use patterns during the first 2 years of treatment: persistent users, episodic users, stop-users and nonusers. Differences in clinical and functional measures during the follow-up period were assessed using linear mixed effects models for the analysis of repeated measures data. Patients who stopped using substances within the first 2 years after diagnosis had outcomes similar to those who had never used with fewer symptoms than episodic or persistent users. Both episodic and persistent users had lower rates of symptom remission than nonusers, and persistent users also had more negative symptoms than those who stopped using. Our findings emerge from one of very few long-term longitudinal studies examining substance use cessation in FEP with 10-year follow-up. The results convey hope that the detrimental effects of substance abuse on mental health may be significantly reversed if one stops the abuse in time. This can help patients who struggle with addiction with their motivation to embrace abstinence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.