ArticleGenome biology and evolution2017
Late Mitochondrial Origin Is an Artifact.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Article
- Eukaryogenesis From FECA to LECA: Radical Steps Along the Way.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Phylogeny-aware Simulations Suggest a Low Impact of Unsampled Lineages in the Inference of Gene Flow During Eukaryogenesis.Genome biology and evolution · 2025Article
- Horizontal gene transfer in eukaryotes: aligning theory with data.Nature reviews. Genetics · 2024Review
- ATP synthase evolution on a cross-braced dated tree of life.Nature communications · 2023Article
- Review
- Ghost lineages can invalidate or even reverse findings regarding gene flow.PLoS biology · 2022Article
- Evidence for a Syncytial Origin of Eukaryotes from Ancestral State Reconstruction.Genome biology and evolution · 2021Article
- Evolutionary Cell Biology (ECB): Lessons, challenges, and opportunities for the integrative study of cell evolution.Journal of biosciences · 2021Article
- Timing the origin of eukaryotic cellular complexity with ancient duplications.Nature ecology & evolution · 2021Article
- Descent of Bacteria and Eukarya From an Archaeal Root of Life.Evolutionary bioinformatics online · 2020Article
- Relative timing of mitochondrial endosymbiosis and the "pre-mitochondrial symbioses" hypothesis.IUBMB life · 2018Review
- Mitonuclear epistasis, genotype-by-environment interactions, and personalized genomics of complex traits in Drosophila.IUBMB life · 2018Article
- Elusive data underlying debate at the prokaryote-eukaryote divide.Biology direct · 2018Article
- Integrated genomic and fossil evidence illuminates life's early evolution and eukaryote origin.Nature ecology & evolution · 2018Article
- Mitochondrial Glycolysis in a Major Lineage of Eukaryotes.Genome biology and evolution · 2018Article
- Mitochondria and cardiovascular diseases-from pathophysiology to treatment.Annals of translational medicine · 2018Review
- Failure to Recover Major Events of Gene Flux in Real Biological Data Due to Method Misapplication.Genome biology and evolution · 2018Article
- Archaea and the origin of eukaryotes.Nature reviews. Microbiology · 2017Review
- Breath-giving cooperation: critical review of origin of mitochondria hypotheses : Major unanswered questions point to the importance of early ecology.Biology direct · 2017Review
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Authors and funding
6 authors.
Funding
Abstract
The origin of mitochondria was a crucial event in eukaryote evolution. A recent report claimed to provide evidence, based on branch length variation in phylogenetic trees, that the mitochondrion came late in eukaryotic evolution. Here, we reinvestigate their claim with a reanalysis of the published data. We show that the analyses underpinning a late mitochondrial origin suffer from multiple fatal flaws founded in inappropriate statistical methods and analyses, in addition to erroneous interpretations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.