Evidence map›Paper›PMID 28199472›Full record

ArticleAmerican journal of hypertension2017

Resequencing Study Identifies Rare Renin-Angiotensin-Aldosterone System Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.

Tanika N Kelly, Changwei Li, James E Hixson, Dongfeng Gu, Dabeeru C Rao, Jianfeng Huang, Treva K Rice, Jichun Chen, Jie Cao, Jianxin Li and 2 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00721721 (Genetic Epidemiology Network of Salt Sensitivity), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00721721 phase3completednot on this map

Genetic Epidemiology Network of Salt Sensitivity

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2003 to 2009Enrolled1,906ConditionsBlood PressureArmsLow Sodium Diet, High Sodium Diet, Potassium Supplementation
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. The association between apelin polymorphisms and hypertension in China: A meta-analysis.Journal of the renin-angiotensin-aldosterone system : JRAAS
    Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Advances in the Genetics of Hypertension: The Effect of Rare Variants.International journal of molecular sciences · 2018
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Tanika N KellyDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Changwei LiDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia at Athens, Athens, Georgia, USA.
James E HixsonDepartment of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA.
Dongfeng GuCardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Jianfeng HuangCardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Jichun ChenCardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China.
Jie CaoCardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China.
Jianxin LiCardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China.
Christopher E AndersonDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Fu Wai Hospital · CNTulane University · USWashington University in St. Louis · USChinese Academy of Medical Sciences & Peking Union Medical College · CNThe University of Texas Health Science Center at Houston · USUniversity of Georgia · US

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI JING CHEN · 2016 to 2026
$25.3M
Genetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6M
Family-Based Genome-wide Association Study for Salt-Sensitivity of Blood PressureR01HL090682 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2008 to 2011
$2.8M
Sodium Sensitivity and Risk of HypertensionR01HL087263 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2007 to 2011
$2.8M
NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS U01 HL072507NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

backgroundThe role of rare variants in blood pressure (BP) salt-sensitivity is unknown. We conducted a resequencing study of the renin-angiotensin-aldosterone system (RAAS) to identify rare variants associated with BP salt-sensitivity among participants of the Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study.

methodsThe GenSalt study was conducted among 1,906 participants who underwent a 7-day low-sodium (51.3 mmol sodium/day) followed by a 7-day high-sodium feeding study (307.8 mmol sodium/day). The 300 most salt-sensitive and 300 most salt-resistant GenSalt participants were selected for the resequencing study. Seven RAAS genes were resequenced using capillary-based sequencing methods. Rare variants were tested for association with BP salt-sensitivity using traditional burden tests. Single-marker analyses were employed to test associations of low-frequency and common variants.

resultsAggregate rare variant analysis revealed an association of the RAAS pathway with BP salt-sensitivity. Carriers of rare RAAS variants had a 1.55-fold [95% confidence interval (CI): 1.15, 2.10] higher odds of salt-sensitivity compared to noncarriers (P = 0.004), a finding which was significant after Bonferroni correction. A nominal association of the APLN gene with salt-sensitivity was also identified, with rare APLN variants conferring a 2.22-fold (95% CI: 1.05, 6.58) higher odds of salt-sensitivity (P = 0.03). Single-marker analyses did not identify variant-BP salt-sensitivity associations after Bonferroni adjustment. A nominal association of a low-frequency, missense RENBP variant was identified. Each minor allele of rs78377269 conferred a 2.21-fold (95% CI: 1.10, 4.42) increased odds of salt-sensitivity (P = 0.03).

conclusionsThis study presents of the first evidence of a contribution of rare RAAS variants to BP salt-sensitivity. Clinical Trial RegistryTrial Number: NCT00721721.

Indexed as

Polymorphism, Single NucleotideAdultApelinBlood PressureCarbohydrate EpimerasesCarrier ProteinsChinaChi-Square DistributionDiet, Sodium-RestrictedFemaleGene FrequencyGenetic Predisposition to DiseaseHumansHypertensionIntercellular Signaling Peptides and ProteinsLinear ModelsApelinAPLN protein, humanCarbohydrate EpimerasesCarrier ProteinsIntercellular Signaling Peptides and ProteinsRENBP protein, humanSodium Chloride, Dietaryblood pressuredietary sodiumgeneticshypertensionrare variantsresequencingsalt sensitivity.

Identifiers

PMID28199472
PMCPMC5861585
OpenAlexW2588572186

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.