ArticleThe Journal of clinical psychiatry
Genetic Risk Score Analysis in Early-Onset Bipolar Disorder.
Article in The Journal of clinical psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Antisocial Personality Disorder in Bipolar Disorder: A Systematic Review.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.Nature communications · 2026Article
- Neuronal guidance signaling in neurodegenerative diseases: Key regulators that function at neuron-glia and neuroimmune interfaces.Neural regeneration research · 2026Article
- Neuronal guidance genes in health and diseases.Protein & cell · 2023Review
- Cell-type-specific genes associated with cortical structural abnormalities in pediatric bipolar disorder.Psychoradiology · 2022Article
- 25 Years of the International Bipolar Collaborative Network (BCN).International journal of bipolar disorders · 2021Review
- Teneurins: Role in Cancer and Potential Role as Diagnostic Biomarkers and Targets for Therapy.International journal of molecular sciences · 2021Review
- Familial aggregation analysis of cognitive performance in early-onset bipolar disorder.European child & adolescent psychiatry · 2020Article
- Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons.Cell · 2020Article
- Association of Cytomegalovirus and Toxoplasma gondii Antibody Titers With Bipolar Disorder.JAMA psychiatry · 2019Article
- Article
- The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research.Bipolar disorders · 2017Review
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveIn this study, we performed a candidate genetic risk score (GRS) analysis of early-onset bipolar disorder (BD).
methodsTreatment of Early Age Mania (TEAM) study enrollment and sample collection took place from 2003 to 2008. Mayo Clinic Bipolar Biobank samples were collected from 2009 to 2013. Genotyping and analyses for the present study took place from 2013 to 2014. The diagnosis of BD was based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Eight single-nucleotide polymorphisms (SNPs), previously reported in genome-wide association studies to be associated with BD, were chosen for GRS analysis in early-onset bipolar disease. These SNPs map to 3 genes: CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit), ANK3 (ankyrin-3, node of Ranvier [ankyrin G]), and ODZ4 (teneurin transmembrane protein 4 [formerly "odz, odd Oz/10-m homolog 4 {Drosophila}, ODZ4"]). The 8 candidate SNPs were genotyped in patients from the TEAM study (n = 69); adult patients with BD (n = 732), including a subset with early-onset illness (n = 192); and healthy controls (n = 776). GRS analyses were performed to compare early-onset cases with controls. In addition, associations of early-onset BD with individual SNPs and haplotypes were explored.
resultsGRS analysis revealed associations of the risk score with early-onset BD (P = .01). Gene-level haplotype analysis comparing TEAM patients with controls suggested association of early-onset BD with a CACNA1C haplotype (global test, P = .01). At the level of individual SNPs, comparison of TEAM cases with healthy controls provided nominally significant evidence for association of SNP rs10848632 in CACNA1C with early-onset BD (P = .017), which did not remain significant after correction for multiple comparisons.
conclusionsThese preliminary analyses suggest that previously identified BD risk loci, especially CACNA1C, have a role in early-onset BD, possibly with stronger effects than for late-onset BD.
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