Trial reportThe Journal of clinical psychiatry
Randomized Controlled Trial Comparing Exercise to Health Education for Stimulant Use Disorder: Results From the CTN-0037 STimulant Reduction Intervention Using Dosed Exercise (STRIDE) Study.
Trial report in The Journal of clinical psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01141608 (NIDA CTN Protocol 0037), which is not on this map. Cited by 49 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NIDA CTN Protocol 0037: Stimulant Reduction Intervention Using Dosed Exercise (STRIDE)
Who cites it
49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Supervised exercise as adjunctive treatment for substance use disorder: Systematic review and meta-analysis.Medicine · 2025Pooled it
- The effects of exercise interventions on substance-use outcomes: A meta-analytic and systematic review.Experimental and clinical psychopharmacology · 2025Pooled it
- Effects of physical exercise interventions on multidimensional health outcomes in patients with substance use disorders: a network meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Pooled it
- The Benefits of Physical Exercise on Mental Disorders and Quality of Life in Substance Use Disorders Patients. Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- The physical activity in cancer survivors (PACES) trial: a factorial randomized trial to optimize intervention for breast cancer survivors.Journal of behavioral medicine · 2024Trial
- Craving among individuals with stimulant use disorder in residential social model-based treatment - Can exercise help?Drug and alcohol dependence · 2022Trial
- Irritability as an independent predictor of concurrent and future suicidal ideation in adults with stimulant use disorder: Findings from the STRIDE study.Journal of affective disorders · 2021Trial
- Cross-Sectional Associations Among Symptoms of Pain, Irritability, and Depression and How These Symptoms Relate to Social Functioning and Quality of Life: Findings From the EMBARC and STRIDE Studies and the VitalSign6 Project.The Journal of clinical psychiatry · 2021Trial
- Psychological and endocannabinoid responses to aerobic exercise in substance use disorder patients.Substance abuse · 2021Trial
- Reinforcing exercise to improve drug abuse treatment outcomes: A randomized controlled study in a substance use disorder outpatient treatment setting.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Trial
- Acute and long-term cannabis use among stimulant users: Results from CTN-0037 Stimulant Reduction Intervention using Dosed Exercise (STRIDE) Randomized Control Trial.Drug and alcohol dependence · 2019Trial
- The effect of exercise as adjunctive treatment on quality of life for individuals with alcohol use disorders: a randomized controlled trial.BMC public health · 2019Trial
- A randomized placebo-controlled trial of N-acetylcysteine for cannabis use disorder in adults.Drug and alcohol dependence · 2017Trial
- Psychosocial relationship status and quality as predictors of exercise intervention adherence and substance use outcomes: Results from the STRIDE (CTN-0037) study.Psychiatry research · 2017Trial
- An ounce of prevention: A pre-randomization protocol to improve retention in substance use disorder clinical trials.Addictive behaviors · 2017Trial
- Racial and ethnic differences in treatment outcomes among adults with stimulant use disorders after a dosed exercise intervention.Journal of ethnicity in substance abuseTrial
- Braining, structured physical activity in specialized psychiatry for patients with substance use disorders-a feasibility study.Pilot and feasibility studies · 2026Article
- The association between sleep disturbance and stimulant use: A cross-lagged examination.Addiction (Abingdon, England) · 2026Article
- Exercise Training Interventions as Therapeutic Approaches in Substance Use Disorder Treatment: A Scoping Review of Direct Clinical Outcomes and Implementation Strategies.Diseases (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 8 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate exercise as a treatment for stimulant use disorders.
methodsThe STimulant Reduction Intervention using Dosed Exercise (STRIDE) study was a randomized clinical trial conducted in 9 residential addiction treatment programs across the United States from July 2010 to February 2013. Of 497 adults referred to the study, 302 met all eligibility criteria, including DSM-IV criteria for stimulant abuse and/or dependence, and were randomized to either a dosed exercise intervention (Exercise) or a health education intervention (Health Education) control, both augmenting treatment as usual and conducted thrice weekly for 12 weeks. The primary outcome of percent stimulant abstinent days during study weeks 4 to 12 was estimated using a novel algorithm adjustment incorporating self-reported Timeline Followback (TLFB) stimulant use and urine drug screen (UDS) data.
resultsMean percent of abstinent days based on TLFB was 90.8% (SD = 16.4%) for Exercise and 91.6% (SD = 14.7%) for Health Education participants. Percent of abstinent days using the eliminate contradiction (ELCON) algorithm was 75.6% (SD = 27.4%) for Exercise and 77.3% (SD = 25.1%) for Health Education. The primary intent-to-treat analysis, using a mixed model controlling for site and the ELCON algorithm, produced no treatment effect (P = .60). In post hoc analyses controlling for treatment adherence and baseline stimulant use, Exercise participants had a 4.8% higher abstinence rate (78.7%) compared to Health Education participants (73.9%) (P = .03, number needed to treat = 7.2).
conclusionsThe primary analysis indicated no significant difference between exercise and health education. Adjustment for intervention adherence showed modestly but significantly higher percent of abstinent days in the exercise group, suggesting that exercise may improve outcomes for stimulant users who have better adherence to an exercise dose.
trial registrationClinicalTrials.gov identifier: NCT01141608.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.