ArticleJournal of applied oral science : revista FOB
Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The systemic effect of prolonged use of sodium alendronate on the peri-implant bone repair process.Journal of applied oral science : revista FOB · 2025Article
- Article
- Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis.International journal of molecular sciences · 2023Article
- The Gradual Release of Alendronate for the Treatment of Critical Bone Defects in Osteoporotic and Control Rats.International journal of nanomedicine · 2023Article
- Feasible low bone density condition for assessing bioactivity in ex-in vivo and in vivo studies.Journal of applied oral science : revista FOB · 2023Article
- Article
- Effect of data binning and frame averaging for micro-CT image acquisition on the morphometric outcome of bone repair assessment.Scientific reports · 2022Article
- Effect of Topical PTH 1-34 Functionalized to BiogranMaterials (Basel, Switzerland) · 2021Article
- Bone Regeneration Assessment of Polycaprolactone Membrane on Critical-Size Defects in Rat Calvaria.Membranes · 2021Article
- Article
- Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Plasma Electrolytic Oxidation as a Feasible Surface Treatment for Biomedical Applications: an in vivo study.Scientific reports · 2020Article
- Decreased microRNA-182-5p helps alendronate promote osteoblast proliferation and differentiation in osteoporosis via the Rap1/MAPK pathway.Bioscience reports · 2018Article
- Dose of alendronate directly increases trabeculae expansivity without altering bone volume in rat femurs.World journal of orthopedics · 2018Article
- Bone repair access of BoneCeramic™ in 5-mm defects: study on rat calvaria.Journal of applied oral science : revista FOB · 2018Article
- A SERM increasing the expression of the osteoblastogenesis and mineralization-related proteins and improving quality of bone tissue in an experimental model of osteoporosis.Journal of applied oral science : revista FOB · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate the bone repair process at the bone/implant interface of osteoporotic rats treated with sodium alendronate through the analysis of microtomography, real time polymerase chain reactions and immunohistochemistry (RUNX2 protein, bone sialoprotein (BSP), alkaline phosphatase, osteopontin and osteocalcin). MATERIAL AND
methodsA total of 42 rats were used and divided in to the following experimental groups: CTL: control group (rats submitted to fictitious surgery and fed with a balanced diet), OST: osteoporosis group (rats submitted to a bilateral ovariectomy and fed with a low calcium diet) and ALE: alendronate group (rats submitted to a bilateral ovariectomy, fed with a low calcium diet and treated with sodium alendronate). A surface treated implant was installed in both tibial metaphyses of each rat. Euthanasia of the animals was conducted at 14 (immunhostochemistry) and 42 days (immunohistochemistry, micro CT and PCR). Data were subjected to statistical analysis with a 5% significance level.
resultsBone volume (BV) and total pore volume were higher for ALE group (P<0.05). Molecular data for RUNX2 and BSP proteins were significantly expressed in the ALE group (P<0.05), in comparison with the other groups. ALP expression was higher in the CTL group (P<0.05). The immunostaining for RUNX2 and osteopontin was positive in the osteoblastic lineage cells of neoformed bone for the CTL and ALE groups in both periods (14 and 42 days). Alkaline phosphatase presented a lower staining area in the OST group compared to the CTL in both periods and the ALE at 42 days.
conclusionThere was a decrease of osteocalcin precipitation at 42 days for the ALE and OST groups. Therefore, treatment with short-term sodium alendronate improved bone repair around the implants installed in the tibia of osteoporotic rats.
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