ArticleScientific reports2017
Risk of other Cancers in Families with Melanoma: Novel Familial Links.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Associations between cutaneous melanoma and prostate cancer: A bidirectional 2-sample Mendelian randomization study.Medicine · 2025Article
- FaMMily Affairs: Dissecting inherited contributions to multiple myeloma risk.Seminars in hematology · 2025Review
- Variant ranking pipeline for complex familial disorders.Scientific reports · 2024Article
- Common skin cancers and their association with other non-cutaneous primary malignancies: a review of the literature.Medical oncology (Northwood, London, England) · 2024Review
- Uncovering genetic associations in the human diseasome using an endophenotype-augmented disease network.Bioinformatics (Oxford, England) · 2024Article
- High- and intermediate-risk susceptibility variants in melanoma families from the Mediterranean area: A multicentre cohort from the MelaNostrum Consortium.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Article
- Incidence of different types of cancer in the follow-up period after primary diagnosis and treatment of melanoma. Single-centre 4-year follow-up on a population of 709 patients.Postepy dermatologii i alergologii · 2023Article
- Article
- Phytochemical Constituents and Derivatives ofInternational journal of molecular sciences · 2023Review
- A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk.HGG advances · 2022Article
- Article
- Review
- Genetic predisposition for multiple myeloma.Leukemia · 2020Review
- Informing patients about their mutation tests: CDKN2A c.256G>A in melanoma as an example.Hereditary cancer in clinical practice · 2020Article
- Impact of family history of cancer on risk and mortality of second cancers in patients with prostate cancer.Prostate cancer and prostatic diseases · 2019Article
- A data driven approach reveals disease similarity on a molecular level.NPJ systems biology and applications · 2019Article
- Biologically ActiveFrontiers in pharmacology · 2019Article
- Familial Risks and Mortality in Second Primary Cancers in Melanoma.JNCI cancer spectrum · 2018Article
- Familial Associations of Colorectal Cancer with Other Cancers.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A family history of cutaneous melanoma ('melanoma') is a well-established risk factor for melanoma. However, less is known about the possible familial associations of melanoma with other discordant cancers. A risk for discordant cancer may provide useful information about shared genetic and environmental risk factors and it may be relevant background data in clinical genetic counseling. Using the Swedish Family-Cancer Database, we assessed the relative risk (RR) for any cancer in families with increasing numbers of first-degree relatives diagnosed with melanoma, including multiple melanoma, and in reverse order RR for melanoma in families of multiple discordant cancers. Close to 9% of melanoma was familial; among these 92% were in 2-case families and 8% in families with 3 cases or more. Cancers that were associated with melanoma, in at least two independent analyses, included breast, prostate, colorectal, skin and nervous system cancers. Other associations included cancer of unknown primary, acute myeloid leukemia/myelofibrosis and Waldenström macroglobulinemia/myeloma. Significant results, which appear biologically plausible, were also obtained for rare nasal melanoma and mesothelioma. Although small samples sizes and multiple comparisons were of concern, many of the above associations were internally consistent and provide new diverse leads for discordant familial association of melanoma.
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