ArticleScientific reports2017
The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Age-Related Decreases in Colonic Neurokinin A Content and Release Monitored Using Electrochemical Immunosensors.Neurogastroenterology and motility · 2026Article
- CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay.EMBO molecular medicine · 2025Article
- Anti-inflammatory and glial response maintain normal colon function in trimethyltin-treated rats.Histochemistry and cell biology · 2024Article
- Prevention of colon enlargement by TNF-α antagonist in a streptozotocin-induced diabetic rat model.Histology and histopathology · 2024Article
- A Framework for an Effective Healthy Longevity Clinic.Aging and disease · 2024Review
- Amperometry approach curve profiling to understand the regulatory mechanisms governing the concentration of intestinal extracellular serotonin.Scientific reports · 2024Article
- Nonlinear DNA methylation trajectories in aging male mice.Nature communications · 2024Article
- Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system.Frontiers in pharmacology · 2024Article
- Article
- Changes in murine anorectum signaling across the life course.Neurogastroenterology and motility · 2018Article
- Interstitial cell network volume is reduced in the terminal bowel of ageing mice.Journal of cellular and molecular medicine · 2018Article
- Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Treatment for chronic constipation in older people is challenging and the condition has a major impact on quality of life. A lack of understanding about the causes of this condition has hampered the development of effective treatments. 5-HT is an important pro-kinetic agent in the colon. We examined whether alterations in colonic 5-HT signalling underlie age-related changes in faecal output in mice and whether these changes were due to an increase in TNF-α. Components of the 5-HT signalling system (5-HT, 5-HIAA, SERT) and TNF-α expression were examined in the distal colon of 3, 12, 18 and 24-month old mice and faecal output and water content monitored under control conditions and following the administration of etanercept (TNF-α inhibitor; 1 mg Kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.