ArticleScientific reports2017
NMR metabolic fingerprints of murine melanocyte and melanoma cell lines: application to biomarker discovery.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Lipid metabolism as a marker for glioma aggressiveness.Bioscience reports · 2026Article
- ¹H-NMR serum metabolomic profiling from clinical routine identifies signatures of progressive melanoma metastasis.Scientific reports · 2026Article
- Lipidomic Analysis Reveals Branched-Chain and Cyclic Fatty Acids fromMolecules (Basel, Switzerland) · 2024Article
- Current Knowledge in Skin Metabolomics: Updates from Literature Review.International journal of molecular sciences · 2022Review
- One extraction tool forJournal of pharmaceutical analysis · 2021Article
- Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma.Molecular oncology · 2021Article
- Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts.Cancers · 2021Article
- Human Melanoma-Cell Metabolic Profiling: Identification of Novel Biomarkers Indicating Metastasis.International journal of molecular sciences · 2020Article
- NMR Spectroscopy for Metabolomics Research.Metabolites · 2019Review
- T-Probe: An Integrated Microscale Device for Online In Situ Single Cell Analysis and Metabolic Profiling Using Mass Spectrometry.Analytical chemistry · 2018Article
- Influence of media selection on NMR based metabolic profiling of human cell lines.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Revealing Different Lung Metastatic Potentials Induced Metabolic Alterations of Hepatocellular Carcinoma Cells via Proton Nuclear Magnetic Resonance Spectroscopy.Journal of Cancer · 2018Article
- Structure of melanins from the fungi Ochroconis lascauxensis and Ochroconis anomala contaminating rock art in the Lascaux Cave.Scientific reports · 2017Article
- Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling.Scientific reports · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanoma is the most aggressive type of skin cancer and efforts to improve the diagnosis of this neoplasia are largely based on the use of cell lines. Metabolomics is currently undergoing great advancements towards its use to screening for disease biomarkers. Although NMR metabolomics includes both 1D and 2D methodologies, there is a lack of data in the literature regarding heteronuclear 2D NMR assignments of the metabolome from eukaryotic cell lines. The present study applied NMR-based metabolomics strategies to characterize aqueous and lipid extracts from murine melanocytes and melanoma cell lines with distinct tumorigenic potential, successfully obtaining fingerprints of the metabolites from the extracts of the cell lines by means of 2D NMR HSQC correlation maps. Relative amounts of the identified metabolites were compared between the 4 cell lines. Multivariate analysis of
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