Evidence map›Paper›PMID 28198363›Full record

ArticleMucosal immunology2017

Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4

B A Szilagyi, J Triebus, C Kressler, M de Almeida, S Tierling, P Durek, M Mardahl, A Szilagyi, S Floess, J Huehn and 4 more

Open access · bronzeAbstract read
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In one paragraph

Article in Mucosal immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

B A SzilagyiExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
J TriebusExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
C KresslerExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
M de AlmeidaExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
S TierlingSaarland University, FR8.3 Genetics/Epigenetics, Saarbrücken, Germany.
P DurekExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
M MardahlExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
A SzilagyiExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
S FloessExperimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
J HuehnExperimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
U SyrbeCharité Universitätsmedizin Berlin, Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany.
J WalterSaarland University, FR8.3 Genetics/Epigenetics, Saarbrücken, Germany.
J K PolanskyExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
A HamannExperimental Rheumatology, Charité Universitätsmedizin Berlin, and Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
German Rheumatism Research Centre · DECharité - Universitätsmedizin Berlin · DEHelmholtz Centre for Infection Research · DESaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of a "topographical memory" in lymphocytes implies a stable expression of homing receptors mediating trafficking of lymphocytes back to the tissue of initial activation. However, a significant plasticity of the gut-homing receptor α

Indexed as

AnimalsCD4-Positive T-LymphocytesCell MovementCells, CulturedDNA MethylationEnhancer Elements, GeneticEpigenesis, GeneticGene Expression RegulationImmunologic MemoryIntegrin alpha4Integrin beta ChainsIntestinesMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Lymphocyte HomingIntegrin alpha4integrin beta7Integrin beta ChainsReceptors, Lymphocyte HomingTretinoin

Identifiers

PMID28198363
OpenAlexW2589089690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.