Evidence map›Paper›PMID 28198109›Full record

ArticleStem cells translational medicine2017

Progenitors in Peripheral Nerves Launch Heterotopic Ossification.

Elizabeth A Olmsted-Davis, Elizabeth A Salisbury, Diana Hoang, Eleanor L Davis, ZaWaunyka Lazard, Corinne Sonnet, Thomas A Davis, Jonathan A Forsberg, Alan R Davis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Complications of cervical total disc replacement and their associations with heterotopic ossification: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
    Pooled it
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  11. A homozygousJBMR plus · 2024
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  19. The diverse origin of bone-forming osteoblasts.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Elizabeth A Olmsted-DavisCenter for Cell and Gene Therapy.
Elizabeth A SalisburyCenter for Cell and Gene Therapy.
Diana HoangCenter for Cell and Gene Therapy.
Eleanor L DavisCenter for Cell and Gene Therapy.
ZaWaunyka LazardCenter for Cell and Gene Therapy.
Corinne SonnetCenter for Cell and Gene Therapy.
Thomas A DavisDepartment of Surgery, Uniformed Services University of the Health Sciences & the Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Jonathan A ForsbergDepartment of Surgery, Uniformed Services University of the Health Sciences & the Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Alan R DavisCenter for Cell and Gene Therapy.
Cell and Gene Therapy Catapult · GBGene Therapy Laboratory · FRBaylor College of Medicine · USUniformed Services University of the Health Sciences · USWalter Reed National Military Medical Center · US

Funding

Research Education and Career Horizons ProgramK12GM084897 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI SIFERS, RICHARD NORMAN, SLAUGHTER, GAYLE · 2008 to 2016
$8.3M
Neural Mechanisms in Heterotopic OssificationR01AR066556 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, ALAN ROBERT · 2014 to 2018
$1.7M
Heterotopic bone from stem cells in peripheral nerves released by neurogenic inflR21AR061638 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, ALAN ROBERT · 2012 to 2013
$379k
Function of Brown Adipose in Bone FormationR21AR063779 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, ELIZABETH ANN · 2013 to 2014
$366k
NIAMS NIH HHS R01 AR066556NIAMS NIH HHS R21 AR061638NIAMS NIH HHS R21 AR063779NIGMS NIH HHS K12 GM084897
6 · The paper itself

Abstract

Studies presented here, using a murine model of bone morphogenetic protein type 2 (BMP2)-induced heterotopic ossification (HO) show that the protein initiates HO by signaling through progenitors in the endoneurium of peripheral nerves. In the mouse, these cells were identified in the endoneurium one day after BMP2 induction using antibody against phosphoSMAD (PS) 1, 5, and 8. Studies conducted in a tracking mouse that contains a tamoxifen-regulated Wnt1-Cre recombinase crossed with a td Tomato red (TR) reporter (Wnt1

Indexed as

AnimalsBone Morphogenetic Protein 2Flow CytometryImmunohistochemistryMaleMiceMice, Inbred C57BLNeural Stem CellsOssification, HeterotopicPeripheral NervesStem CellsWounds and InjuriesBone Morphogenetic Protein 2Blood-nerve barrierBone morphogenetic type 2Heterotopic ossificationNeural stem cellsTrauma

Identifiers

PMID28198109
PMCPMC5442844
OpenAlexW2589104060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.