Evidence map›Paper›PMID 28197887›Full record

ArticlePediatric nephrology (Berlin, Germany)2017

The ISKDC classification and a new semiquantitative classification for predicting outcomes of Henoch-Schönlein purpura nephritis.

Mikael Koskela, Elisa Ylinen, Elli-Maija Ukonmaanaho, Helena Autio-Harmainen, Päivi Heikkilä, Jouko Lohi, Outi Jauhola, Jaana Ronkainen, Timo Jahnukainen, Matti Nuutinen

Open access · greenAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Mikael KoskelaDepartment of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital and University of Helsinki, PO Box 281, 00029, Helsinki, Finland. mikael.koskela@helsinki.fi.
Elisa YlinenDepartment of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital and University of Helsinki, PO Box 281, 00029, Helsinki, Finland.
Elli-Maija UkonmaanahoDepartment of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
Helena Autio-HarmainenMedical Research Center Oulu and Department of Pathology, Oulu University Hospital, Oulu, Finland.
Päivi HeikkiläDepartment of Pathology, Helsinki University Hospital, Helsinki, Finland.
Jouko LohiDepartment of Pathology, Helsinki University Hospital, Helsinki, Finland.
Outi JauholaDepartment of Pediatrics, Hyvinkää Hospital, Hyvinkää, Finland.
Jaana RonkainenOulu City Health Care Centre, Oulu, Finland.
Timo JahnukainenDepartment of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital and University of Helsinki, PO Box 281, 00029, Helsinki, Finland.
Matti NuutinenDepartment of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
Helsinki University Hospital · FIOulu University Hospital · FIHyvinkää Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHistological findings from primary kidney biopsies were correlated with patient outcomes in a national cohort of paediatric Henoch-Schönlein nephritis (HSN) patients.

methodsPrimary kidney biopsies from 53 HSN patients were re-evaluated using the ISKDC (International Study of Kidney Disease in Children) classification and a modified semiquantitative classification (SQC) that scores renal findings and also takes into account activity, chronicity and tubulointerstitial indices. The ISKDC and SQC classifications were evaluated comparatively in four outcome groups: no signs of renal disease (outcome A, n = 27), minor urinary abnormalities (outcome B, n = 18), active renal disease (outcome C, n = 3) and renal insufficiency, end-stage renal disease or succumbed due to HSN (outcome D, n = 5). For the receiver operating characteristic and logistic regression analyses, outcomes A and B were considered to be favourable and outcomes C and D to be unfavourable. The median follow-up time was 7.3 years.

resultsThe patients with an unfavourable outcome (C and D), considered together due to low patient numbers, had significantly higher total biopsy SQC scores and activity indices than those who had a favourable one (groups A and B). The chronicity and tubulointerstitial indices differed significantly only between group C + D and group A. The difference in areas under the curve between the total biopsy SQC scores and ISKDC findings was 0.15 [p = 0.04, normal-based 95% confidence interval (CI) 0.007-0.29, bias-controlled 95% CI -0.004 to 0.28].

conclusionsOur results suggest that the modified SQC is more sensitive than ISKDC classification for predicting the outcome in HSN cases.

Indexed as

AdolescentBiopsyChildFeasibility StudiesFemaleFollow-Up StudiesGlomerular Filtration RateHumansIgA VasculitisKidneyKidney Failure, ChronicMaleNephritisPrognosisProteinuriaRetrospective StudiesChildrenGlomerulonephritisHistologyRenal biopsySemiquantitativeVasculitis

Identifiers

PMID28197887
OpenAlexW2588655588

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.