ArticleBrain imaging and behavior2018
Local resting state functional connectivity in autism: site and cohort variability and the effect of eye status.
Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Atypical local brain connectivity in pediatric autism spectrum disorder? A coordinate-based meta-analysis of regional homogeneity studies.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- Resting-state abnormalities in Autism Spectrum Disorders: A meta-analysis.Scientific reports · 2019Pooled it
- Cortical Network Overconnectivity Relates to Sensory, Cognitive, and Social Dimensions in Young Children With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Cerebellar Contributions to Cerebral Connectivity in Severe Mental Illness: A Developmental Cascade and Predictive-Modeling Framework with Autistic Disorder as the Focal Case.Brain sciences · 2026Review
- Alterations in self-related brain networks in autism spectrum disorder: a systematic review of functional and structural magnetic resonance imaging studies.Psychoradiology · 2026Review
- Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes.Nature communications · 2025Article
- Contrast subgraphs catch patterns of altered functional connectivity in autism spectrum disorder.Scientific reports · 2025Article
- Improving brain difference identification in autism spectrum disorder through enhanced head motion correction in ICA-AROMA.Communications biology · 2025Article
- Sex differences of signal complexity at resting-state functional magnetic resonance imaging and their associations with the estrogen-signaling pathway in the brain.Cognitive neurodynamics · 2024Article
- EEG Microstates as Markers for Cognitive Impairments in Fragile X Syndrome.Brain topography · 2024Article
- Role of Artificial Intelligence for Autism Diagnosis Using DTI and fMRI: A Survey.Biomedicines · 2023Article
- Article
- Regional homogeneity of adolescents with high-functioning autism spectrum disorder and its association with symptom severity.Brain and behavior · 2022Article
- Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder.Nature communications · 2022Article
- Blood Oxygen Level-Dependent Lag Patterns Differ Between Rest and Task Conditions, but Are Largely Typical in Autism.Brain connectivity · 2022Article
- Resting state EEG in youth with ASD: age, sex, and relation to phenotype.Journal of neurodevelopmental disorders · 2021Article
- Co-activation pattern alterations in autism spectrum disorder-A volume-wise hierarchical clustering fMRI study.Brain and behavior · 2021Article
- Performance of machine learning classification models of autism using resting-state fMRI is contingent on sample heterogeneity.Neural computing & applications · 2021Article
- Altered Fractional Amplitude of Low-Frequency Fluctuation in Major Depressive Disorder and Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Alterations of Regional Homogeneity in Preschool Boys With Autism Spectrum Disorders.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with prominent impairments in sociocommunicative abilities, which have been linked to anomalous brain network organization. Despite ample evidence of atypical long-distance connectivity, the literature on local connectivity remains small and divergent. We used resting-state functional MRI regional homogeneity (ReHo) as a local connectivity measure in comparative analyses across several well-matched low-motion subsamples from the Autism Brain Imaging Data Exchange and in-house data, with a grand total of 147 ASD and 184 typically developing (TD) participants, ages 7-18 years. We tested for group differences in each subsample, with additional focus on the difference between eyes-open and eyes-closed resting states. Despite selection of highest quality data and tight demographic and motion matching between groups and across samples, few effects in exactly identical loci (voxels) were found across samples. However, there was gross consistency across all eyes-open samples of local overconnectivity (ASD > TD) in posterior, visual regions. There was also gross consistency of local underconnectivity (ASD < TD) in cingulate gyrus, although exact loci varied between mid/posterior and anterior sections. While all eyes-open datasets showed the described gross similarities, the pattern of group differences for participants scanned with eyes closed was different, with local overconnectivity in ASD in posterior cingulate gyrus, but underconnectivity in some visual regions. Our findings suggest that fMRI local connectivity measures may be relatively susceptible to site and cohort variability and that some previous inconsistencies in the ASD ReHo literature may be reconciled by more careful consideration of eye status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.