SynthesisIntensive care medicine2017
Contrast-associated acute kidney injury in the critically ill: systematic review and Bayesian meta-analysis.
Synthesis in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- A Systematic Bibliometric Analysis of High-Impact Articles in Critical Care Nephrology.Blood purification · 2024Pooled it
- Risk of acute kidney injury after contrast-enhanced computerized tomography: a systematic review and meta-analysis of 21 propensity score-matched cohort studies.European radiology · 2022Pooled it
- Point-of-care creatinine tests to assess kidney function for outpatients requiring contrast-enhanced CT imaging: systematic reviews and economic evaluation.Health technology assessment (Winchester, England) · 2020Pooled it
- Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 : Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine.Intensive care medicine · 2017Pooled it
- Early and delayed acute kidney injury after contrast-enhanced CT in critically ill adults: a target trial emulation.Emergency radiology · 2026Article
- Observational
- Predictive value of the uric acid-to-albumin ratio for contrast-induced nephropathy after percutaneous coronary intervention and construction of a clinical prediction model in patients with coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- Gastrointestinal complications in intensive care.Medical review (2021) · 2025Review
- Acute Kidney Injury After Peripheral Interventions Using Carbon Dioxide Angiography-Risk Factors Beyond Iodinated Contrast Media.Life (Basel, Switzerland) · 2025Article
- Ten tips for managing caustic ingestion in adult patients.Intensive care medicine · 2025Article
- The Crucial Question About Contrast-Induced Nephropathy (CIN): Should It Affect Clinical Practice?Pharmaceuticals (Basel, Switzerland) · 2025Review
- Massive intestinal mesenteric portal vein ischemia: Percutaneous endovascular thrombolysis as minimally invasive step-up approach.Turkish journal of surgery · 2025Article
- Predictive ability of serum osmolarity for contrast-induced nephropathy after elective percutaneous coronary intervention: Are we having a new target?The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Management of acute myocardial infarction in chronic kidney disease in Germany: an observational study.BMC nephrology · 2025Observational
- Association Between IV Contrast Media Exposure and Acute Kidney Injury in Patients Requiring Emergency Admission: A Nationwide Observational Study in Japan.Critical care explorations · 2024Observational
- Association between Pan-Immune-Inflammation Value and Contrast-Induced Nephropathy with Coronary Angiography.Medicina (Kaunas, Lithuania) · 2024Article
- The use of intravascular contrast media in patients with impaired kidney function - joint clinical practice position statement of the Polish Society of Nephrology and the Polish Medical Society of Radiology.Polish journal of radiology · 2024Review
- Article
- Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data.Clinical kidney journal · 2023Article
- Predictive value of CHAThe Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
purposeCritically ill patients, among whom acute kidney injury is common, are often considered particularly vulnerable to iodinated contrast medium nephrotoxicity. However, the attributable incidence remains uncertain given the paucity of observational studies including a control group. This study assessed acute kidney injury incidence attributable to iodinated contrast media in critically ill patients based on new data accounting for sample and effect size and including a control group.
methodsSystematic review of studies measuring incidence of acute kidney injury in critically ill patients following contrast medium exposure compared to matched unexposed patients. Patient-level meta-analysis implementing a Bayesian nested mixed effects multiple logistic regression model.
resultsTen studies were identified; only four took into account the baseline acute kidney injury risk, three by patient matching (560 patients). Objective meta-analysis of these three studies (vague and impartial a priori hypothesis concerning attributable acute kidney injury risk) did not find that iodinated contrast media increased the incidence of acute kidney injury (odds ratio 0.95, 95% highest posterior density interval 0.45-1.62). Bayesian analysis demonstrated that, to conclude in favor of a statistically significant incidence of acute kidney injury attributable to contrast media despite this observed lack of association, one's a priori belief would have to be very strongly biased, assigning to previous uncontrolled reports 3-12 times the weight of evidence strength provided by the matched studies including a control group.
conclusionsMeta-analysis of matched cohort studies of iodinated contrast medium exposure does not support a significant incidence of acute kidney injury attributable to iodinated contrast media in critically ill patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.