ArticlePsychopharmacology2017
Effects of early life stress and adolescent ethanol exposure on adult cognitive performance in the 5-choice serial reaction time task in Wistar male rats.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Combined maternal separation and limited bedding-nesting increase goal tracking, delay discounting, and impulsive action, and moderate sign-tracking-perseverance associations in male rats.BMC neuroscience · 2026Article
- Dependence of psychopharmacological drug effects on early social stress experience: An analysis aligned with the research domain criteria framework.The Journal of pharmacology and experimental therapeutics · 2025Review
- Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood.Neurobiology of learning and memory · 2025Article
- Modulation of the p75NTR during Adolescent Alcohol Exposure Prevents Cholinergic Neuronal Atrophy and Associated Acetylcholine Activity and Behavioral Dysfunction.International journal of molecular sciences · 2024Article
- Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline.Neurobiology of stress · 2024Article
- Effects of combined use of alcohol and delta-9-tetrahydrocannibinol on working memory in Long Evans rats.Behavioural brain research · 2023Article
- Effects of combined use of alcohol and delta-9-tetrahydrocannibinol on working memory in Long Evans rats.bioRxiv : the preprint server for biology · 2023Article
- CaMKIIα neurons in the anterior insular cortex regulate attention behavior in mice.Frontiers in neural circuits · 2023Article
- The effects of early life stress on impulsivity.Neuroscience and biobehavioral reviews · 2022Review
- Short-term Montreal Cognitive Assessment predicts functional outcome after endovascular therapy.Frontiers in aging neuroscience · 2022Article
- Impaired cognitive flexibility and heightened urgency are associated with increased alcohol consumption in rodent models of excessive drinking.Addiction biology · 2021Article
- Stress Regulation of Sustained Attention and the Cholinergic Attention System.Biological psychiatry · 2020Article
- The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents.Neurobiology of learning and memory · 2020Review
- Article
- Chronic voluntary alcohol consumption causes persistent cognitive deficits and cortical cell loss in a rodent model.Scientific reports · 2019Article
- Effect of early maternal separation stress on attention, spatial learning and social interaction behaviour.Experimental brain research · 2019Article
- Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Age and impulsive behavior in drug addiction: A review of past research and future directions.Pharmacology, biochemistry, and behavior · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleEarly life stress combined with heavy adolescent alcohol use predicts impaired neuropsychological functioning in adulthood. We investigated whether adolescent intermittent ethanol (AIE) exposure combined with neonatal maternal separation in rats altered attentional processes and impulsivity in adulthood.
methodsMale Wistar rat pups were exposed to maternal separation (postnatal days (PNDs) 1-14) and moderate AIE exposure (PNDs 28-57). Adult rats were tested in the five-choice serial reaction time task, which provides separate measures of attention, motor impulsivity, and compulsivity. Rats were tested under baseline conditions and in response to task manipulations that increased attentional load and impulsive behaviors, and after acute ethanol administration.
resultsShort stimulus and short intertrial interval (ITI) durations disrupted attention while long ITI durations impaired impulsivity in all rats. Moderate- and high-dose ethanol challenges impaired attention in all rats. Rats exposed to maternal separation and/or AIE exposure had significantly decreased omissions than non-handled water-exposed rats at baseline and tended to retain this effect in response to task challenges (i.e., the shorter stimulus and ITI durations, longer test session) and ethanol challenges, indicating moderate improvement of attentional performance. Maternal separation significantly increased perseverative responses at baseline and in response to decreased stimulus duration challenge, suggesting increased compulsivity.
conclusionsSeparate or combined exposure to early life stress and AIE exposure moderately disrupts some aspects of adult executive control functions (e.g., increased compulsivity) but improves others (e.g., increased attention). The relative intensity of either manipulation during neonatal and adolescent periods may influence the direction in which cognitive behaviors are affected in adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.